PMID: 8610967Feb 13, 1996Paper

The role of chemokines in oral tolerance. Abrogation of nonresponsiveness by treatment with antimonocyte chemotactic protein-1

Annals of the New York Academy of Sciences
W J Karpus, N W Lukacs

Abstract

Peripheral antigen-specific tolerance can be induced by feeding protein antigens. The mechanism has been described as either clonal anergy/deletion or induction of antigen-specific regulatory cells that produce transforming growth factor (TGF)-beta, depending on the dose of antigen fed. Experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, can be prevented by feeding myelin basic protein (MBP) or proteolipid protein (PLP). We decided to address the role of chemokines in the induction of oral tolerance. We have used a model antigen system of feeding a high dose of human gamma globulin (HGG) to mice that have been subsequently immunized with HGG emulsified in CFA. The result was decreased recall proliferative, delayed-type hypersensitivity (DTH) and Th1 cytokine responses. By contrast, Th2 cytokine responses were enhanced. Interestingly, macrophage inflammatory protein (MIP)-1alpha production was decreased, whereas monocyte chemotactic protein (MCP)-1 production was enhanced. Induction of oral tolerance was prevented by the administration of anti-MCP-1 to mice fed HGG. These results show that chemokines play an important role in the induction of oral tolerance.

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Citations

Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·R William DePaoloWilliam J Karpus
Nov 24, 1999·Immunological Reviews·C CzerkinskyJ B Sun
May 25, 2002·Scandinavian Journal of Immunology·F M OliveiraC M Gontijo
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graciela CascioMario Mellado
Jan 27, 1999·Arthritis and Rheumatism·G J ThorbeckeW J Simmons
Oct 31, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Udai P SinghJames W Lillard
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D E FaunceJ Stein-Streilein
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·R William DePaoloWilliam J Karpus
Mar 1, 2000·Multiple Sclerosis : Clinical and Laboratory Research·G X ZhangA M Rostami

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