The role of chemotherapy in the current treatment of gastric cancer

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Eric Van CutsemA Ohtsu

Abstract

Metaanalyses of adjuvant systemic chemotherapy in gastric cancer have shown at best marginal benefits, although a recent trial of postoperative chemoradiotherapy has demonstrated significantly increased overall survival. Neoadjuvant chemotherapy and chemoradiotherapy are also feasible and are the subject of several ongoing studies. This setting may provide valuable evidence of the activity of new agents and the chemosensitivity of specific tumors. In metastatic disease, chemotherapy confers benefit when compared with best supportive care alone. No particular regimen has been shown to be superior to others in this context, and there is a pressing need for the evaluation of newer agents such as the oral fluoropyrimidines, taxanes, irinotecan, and oxaliplatin.

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Citations

Jul 13, 2005·Cancer Chemotherapy and Pharmacology·Se Hoon ParkDong Bok Shin
Oct 30, 2008·Surgery Today·Yasunori EmiYoshihiko Maehara
Jan 24, 2006·Anti-cancer Drugs·Junichi SakamotoUNKNOWN Clinical Study Group of Capecitabine
Aug 19, 2004·International Journal of Cancer. Journal International Du Cancer·Wataru IchikawaRenzo Hirayama
Mar 24, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kazuhiro NishikawaToshimasa Tsujinaka
Sep 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung Tae KimWon Ki Kang
Feb 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S BlankK Ott
Mar 14, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jung Hun KangSe Hoon Park
Apr 9, 2005·World Journal of Gastroenterology : WJG·Jun ZhangYan-Zhen Lin
Aug 8, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Der Sheng SunYoon Ho Ko
Oct 17, 2014·World Journal of Gastroenterology : WJG·Keishiro AoyagiKazuo Shirouzu
Aug 14, 2015·World Journal of Gastroenterology : WJG·Sung Min Kim, Se Hoon Park
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lynne W ElmoreDavid A Gewirtz

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