The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients.

Pharmacological Reports : PR
Dominika BerentMarcin Wojnar

Abstract

Alcohol-dependent (AD) patients report higher number of adverse childhood experiences (ACEs), develop poor social skills, and have a higher rate of suicide attempts than the general population. We hypothesize that the association between ACEs and lifetime suicide attempts in AD patients is mediated by generalized self-efficacy and selected functional single nucleotide polymorphisms (SNPs) in genes involved in the stress response and neuroplasticity, including: FKBP5 rs1360780, BDNF rs6265, and NRN1 rs1475157. 176 AD patients and 127 healthy controls self-reported ACEs with the ACE Study questionnaire and three additional questions that inquired about ACE categories of acute stress; generalized self-efficacy-with the Generalized Self-Efficacy Scale. Genotyping for the three analysed SNPs was performed according to the manufacturer's standard PCR protocol. Hypotheses were tested with bivariate analyses, multiple regression model, and mediation models. Higher levels of generalized self-efficacy were associated with a blunted effect of ACEs on the risk of suicide attempts. The prevalence of the three analyzed SNPs genotypes and alleles did not differ between AD patients with a positive vs. negative lifetime history of suicide attem...Continue Reading

References

Mar 1, 1975·Archives of General Psychiatry·E S PaykelJ K Myers
May 29, 2004·Alcoholism, Clinical and Experimental Research·Kenneth R Conner, Paul R Duberstein
Jan 5, 2006·Acta Psychiatrica Scandinavica·L Sher
Aug 15, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku KimSo-Hyun Choi
Nov 30, 2006·Psychology, Health & Medicine·Paul KennedyLynne Hindson
Nov 30, 2006·Psychology, Health & Medicine·J H BarlowHannah Williams
Feb 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Matthew K NockDavid Williams
Oct 7, 2008·Journal of Affective Disorders·Marcin WojnarKirk J Brower
Sep 8, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Sylwia FudalejFrederic C Blow
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alec RoyMary-Anne Enoch
May 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Laila Cigana SchenkelSandra Leistner-Segal
Oct 12, 2010·Drug and Alcohol Dependence·Georg SchomerusMichael Lucht
Nov 30, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Irwan SupriyantoAkitoyo Hishimoto
Jan 24, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angela CarballedoThomas Frodl
Jun 24, 2014·Annals of Epidemiology·Mark S KaplanKurt B Nolte
Jul 6, 2014·Biological Psychiatry·Jamie L HansonRichard J Davidson
Jul 7, 2014·Child Abuse & Neglect·A JakubczykM Wojnar
Jul 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ryan BogdanAhmad R Hariri
Dec 3, 2015·Neuropsychobiology·Sylwia FudalejRafał Płoski
Jun 12, 2016·Addiction·Emre Bora, Nabi Zorlu
Jul 5, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Theo Rein
Jun 28, 2017·Psychoneuroendocrinology·Thorhildur HalldorsdottirElisabeth B Binder
Sep 20, 2017·Translational Neuroscience·Dominika BerentZofia Pawłowska
Nov 7, 2017·Translational Neuroscience·Dominika BerentZofia Pawłowska
Dec 1, 2017·Frontiers in Psychology·Robert Agler, Paul De Boeck

❮ Previous
Next ❯

Software Mentioned

AUDIT

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.