The role of cholesterol on the activity and stability of neurotensin receptor 1.

Biochimica Et Biophysica Acta
Joanne OatesAnthony Watts

Abstract

Understanding the role of specific bilayer components in controlling the function of G-protein coupled receptors (GPCRs) will be a key factor in the development of novel pharmaceuticals. Cholesterol-dependence in particular has become an area of keen interest with respect to GPCR function; not least since the 2.6Å crystal structure of the β2 adrenergic receptor revealed a putative cholesterol binding motif conserved throughout class-A GPCRs. Furthermore, experimental evidence for cholesterol-dependent GPCR function has been demonstrated in a limited number of cases. This modulation of receptor function has been attributed to both direct interactions between cholesterol and receptor, and indirect effects caused by the influence of cholesterol on bilayer order and lateral pressure. Despite the widespread occurrence of cholesterol binding motifs, available experimental data on the functional involvement of cholesterol on GPCRs are currently limited to a small number of receptors. Here we investigate the role of cholesterol in the function of the neurotensin receptor 1 (NTS1) a class-A GPCR. Specifically we show how cholesterol, and the analogue cholesteryl hemisuccinate, influence activity, stability, and oligomerisation of both p...Continue Reading

References

Dec 8, 1989·European Journal of Biochemistry·Y OhtaniJ Pitha
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S MarulloL Emorine
Feb 5, 1980·Biochemistry·J L RubensteinH M McConnell
Aug 1, 1996·The Biochemical Journal·J Tucker, R Grisshammer
Sep 13, 1996·Biochimica Et Biophysica Acta·A D AlbertR M Epand
Nov 13, 1996·Biochimica Et Biophysica Acta·A D AlbertP L Yeagle
Sep 9, 1997·Biochemistry·G GimplF Fahrenholz
Oct 3, 1999·Biochemistry·L PangS Wang
Mar 10, 2001·Trends in Pharmacological Sciences·A D HowardA A Patchett
May 16, 2002·Biochemistry·Ana Vitória BotelhoMichael F Brown
Jul 5, 2002·The Journal of Biological Chemistry·Yang XiangBrian Kobilka
Aug 15, 2002·Biochimica Et Biophysica Acta·Gerald Gimpl, Falk Fahrenholz
Oct 4, 2002·Chembiochem : a European Journal of Chemical Biology·Thomas Klabunde, Gerhard Hessler
Jan 14, 2003·Biophysical Journal·Thomas M WeissHuey W Huang
Apr 28, 2004·FEBS Letters·Jim F WhiteReinhard Grisshammer
Feb 3, 2005·Molecular Pharmacology·Robert Fredriksson, Helgi B Schiöth
Oct 8, 2005·Journal of Structural and Functional Genomics·Reinhard GrisshammerJoseph Shiloach
Sep 9, 2006·The Journal of Biological Chemistry·Olivier SoubiasKlaus Gawrisch
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jim F WhiteReinhard Grisshammer
Feb 12, 2008·Biochimica Et Biophysica Acta·Alexander I GreenwoodStephanie Tristram-Nagle
Sep 20, 2008·Glycoconjugate Journal·Rajesh PrasadAmitabha Chattopadhyay
Nov 4, 2008·Protein Expression and Purification·Helen AttrillAnthony Watts
May 26, 2009·ACS Chemical Biology·Rebecca M MyersSteven V Ley
Dec 15, 2010·Biochemical and Biophysical Research Communications·Md JafurullaAmitabha Chattopadhyay
Nov 1, 2011·Current Opinion in Structural Biology·Joanne Oates, Anthony Watts

❮ Previous
Next ❯

Citations

Nov 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael ZocherDaniel J Müller
Feb 15, 2014·Journal of Molecular Modeling·Waldemar KuligPavel Jungwirth
Mar 8, 2016·Biochimica Et Biophysica Acta·Mariusz Kepczynski, Tomasz Róg
Nov 17, 2015·Nature Chemical Biology·Rosie DawalibyCédric Govaerts
Mar 2, 2016·Biochimica Et Biophysica Acta·Juan H BolivarAnthony Watts
Aug 16, 2015·Biochimica Et Biophysica Acta·Patricia M Dijkman, Anthony Watts
Jun 13, 2015·The Journal of Membrane Biology·Zoe CourniaAna-Nicoleta Bondar
Jun 12, 2014·Biological Reviews of the Cambridge Philosophical Society·Ruth NussinovChung-Jung Tsai
Jul 28, 2015·Pharmacology Research & Perspectives·O J MaceF Marshall
Feb 1, 2014·Current Opinion in Cell Biology·Rinshi S Kasai, Akihiro Kusumi
Mar 31, 2015·Biochimica Et Biophysica Acta·Durba Sengupta, Amitabha Chattopadhyay
Jun 12, 2016·Biochimica Et Biophysica Acta·Sai Prasad PydiAmitabha Chattopadhyay
Aug 19, 2016·Scientific Reports·Xavier PrasannaAmitabha Chattopadhyay
Oct 21, 2015·Biochemistry·Adam T ClayFrances J Sharom
Jul 22, 2016·British Journal of Pharmacology·Louise E See HoeJason N Peart
Oct 26, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Feroz Ahmed ShaikPrashen Chelikani
May 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Metehan IlterOzge Sensoy
Oct 12, 2019·Journal of Computational Chemistry·Apurba BhattaraiYinglong Miao
Feb 8, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Parijat Sarkar, Amitabha Chattopadhyay
May 2, 2015·The Journal of Biological Chemistry·Sara MarsangoGraeme Milligan
May 30, 2019·International Journal of Molecular Sciences·Tristan O C KwanIsabel Moraes
Mar 15, 2015·Molecular Pharmacology·María José Varela ListeGraeme Milligan
Aug 28, 2020·Science Advances·Patricia M DijkmanAnthony Watts
Nov 25, 2020·The Journal of Membrane Biology·Stephanie E Crilly, Manojkumar A Puthenveedu
Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrew J Y JonesDaniel Nietlispach
Nov 15, 2020·Biophysics Reviews·Parijat SarkarAmitabha Chattopadhyay
Aug 28, 2020·Chemistry and Physics of Lipids·Sarosh N FatakiaAmitabha Chattopadhyay
Jul 25, 2021·Science Advances·G Aditya KumarAmitabha Chattopadhyay
Mar 24, 2020·The Journal of Physical Chemistry. B·Stefan Gahbauer, Rainer A Böckmann
Feb 14, 2019·Chemical Reviews·Valentina CorradiD Peter Tieleman
Nov 2, 2019·The Journal of Physical Chemistry. B·Bozena AugustynTomasz Róg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.