PMID: 6108078Nov 1, 1980Paper

The role of cholinergic supersensitivity in the medical symptoms associated with withdrawal of antipsychotic drugs

The American Journal of Psychiatry
D J LuchinsR J Wyatt

Abstract

From a review of the clinical literature, the authors determined that the medical symptoms of neuroleptic withdrawal occurred more frequently with neuroleptics having potent anticholinergic effects than with those having weak anticholinergic actions. When antiparkinsonian agents were not simultaneously withdrawn, there was a striking difference between these two categories of neuroleptics. Experiments with mice showed that withdrawal of haloperidol, a neuroleptic with weak anticholinergic effects, produced subsensitivity (depression of locomotor activity and seizure thresholds) to the cholinergic effects of physostigmine. These findings support the theory that the medical side effects of neuroleptic withdrawal are due to rebound cholinergic hypersensitivity associated with the anticholinergic actions of these drugs, rather than being related to their dopamine-blocking activity.

Citations

Jan 1, 1983·Psychopharmacology·B WistedtA Jørgensen
Jan 1, 1992·Psychopharmacology·O Pucilowski
Nov 7, 2002·Current Medical Research and Opinion·J Peuskens
May 6, 2008·Journal of Psychiatric and Mental Health Nursing·M Jones, A Jones
Nov 1, 1988·Journal of the American Geriatrics Society·S L Kishnir
Jun 13, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Irma ConvertinoMarco Tuccori
Mar 1, 1988·Acta Psychiatrica Scandinavica·S C Dilsaver, N E Alessi
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·J StaedtE Ruther
Jul 1, 2010·Expert Review of Clinical Pharmacology·Clare V BostockArduino A Mangoni
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