The Role of Chorioretinal Biopsy in the Diagnosis of Intraocular Lymphoma

American Journal of Ophthalmology
Rodolfo MastropasquaLyndon da Cruz

Abstract

To assess the clinical usefulness of chorioretinal biopsy in establishing a definitive diagnosis in intraocular lymphomas. Retrospective, noncomparative, consecutive diagnostic case series. setting: Moorfields Eye Hospital, London, United Kingdom. Twenty-nine consecutive patients presenting with severe uveitis that required an intraocular biopsy where underlying lymphoma was suspected. A retrospective review of a 15-year period (1999-2014) was undertaken of all patients that have undergone chorioretinal biopsy for suspected lymphoma at Moorfields Eye Hospital, London, United Kingdom. Patients were identified on the hospital's computerized database. Effectiveness of chorioretinal biopsy in establishing a definitive diagnosis or in excluding malignancy. A specific histologic diagnosis was made in 17 cases (59%) while in 9 cases the biopsy combined with clinical data was effective in excluding malignancy. In the 3 remaining cases, no specific diagnosis was made. No intraoperative complications were reported. Postoperative complications other than cataract included 2 vitreous hemorrhages and 2 retinal detachments. Of the 17 cases with a histologic diagnosis, 15 were obtained in eyes with marked vitritis, as opposed to 2 with minima...Continue Reading

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Citations

Feb 10, 2016·Current Opinion in Ophthalmology·David Reichstein
Aug 23, 2020·Indian Journal of Ophthalmology·Gazal PatnaikJyotirmay Biswas
Aug 23, 2020·Indian Journal of Ophthalmology·Reema BansalAtul Kumar
Feb 24, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Justus G Garweg
Jan 11, 2019·Case Reports in Ophthalmological Medicine·Krishi PeddadaWeiye Li
Oct 23, 2019·Journal of Clinical Medicine·Rodolfo MastropasquaLyndon da Cruz
May 27, 2020·Ocular Immunology and Inflammation·Jonel SteffenJustine R Smith
Mar 19, 2021·Eye·Elewys HearneSue Lightman
May 20, 2021·Ocular Immunology and Inflammation·Denise CarbonellUNKNOWN Study Group for Vitreoretinal Lymphoma Diagnostics
Aug 20, 2021·American Journal of Ophthalmology Case Reports·Mainguy AdamTouhami Sara
Nov 7, 2019·Case Reports in Ophthalmology·Andrew W KamAdrian T Fung

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