The role of chromatin dynamics under global warming response in the symbiotic coral model Aiptasia

Communications Biology
Eviatar Weizman, Oren Levy

Abstract

Extreme weather events frequency and scale are altered due to climate change. Symbiosis between corals and their endosymbiotic-dinoflagellates (Symbiodinium) is susceptible to these events and can lead to what is known as bleaching. However, there is evidence for coral adaptive plasticity in the role of epigenetic that have acclimated to high-temperature environments. We have implemented ATAC-seq and RNA-seq to study the cnidarian-dinoflagellate model Exaptasia pallida (Aiptasia) and expose the role of chromatin-dynamics in response to thermal-stress. We have identified 1309 genomic sites that change their accessibility in response to thermal changes. Moreover, apo-symbiotic Aiptasia accessible sites were enriched with NFAT, ATF4, GATA3, SOX14, and PAX3 motifs and expressed genes related to immunological pathways. Symbiotic Aiptasia accessible sites were enriched with NKx3-1, HNF4A, IRF4 motifs and expressed genes related to oxidative-stress pathways. Our work opens a new path towards understanding thermal-stress gene regulation in association with gene activity and chromatin-dynamics.

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Datasets Mentioned

BETA
PRJNA518019

Methods Mentioned

BETA
environmental stress
immunoprecipitation
Assay
ATAC-seq
thermal stress
ChIP-seq
RNA-seq
PCR

Software Mentioned

HOMER
MACS2
- Win
BEDTools
R BIOCONDUCTOR package GPLOTS
bowtie
Imaging
DESeq2
Heatmap
SPSS

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