PMID: 7333707Dec 1, 1981Paper

The role of chromosome 15 in murine leukemogenesis. I. Contrasting behavior of the tumor vs. normal parent-derived chromosomes No. 15 in somatic hybrids of varying tumorigenicity

International Journal of Cancer. Journal International Du Cancer
J SpiraG Klein

Abstract

G-banding analysis was carried out on a series of hybrids derived from the fusion of a chromosome 15-trisomic murine T-cell leukemia of AKR origin and normal diploid fibroblasts or lymphocytes of the CBT6T6 strain. Due to the 14;15 translocation involved in the generation of the T6 marker, the chromosomes No. 15 and 14 derived from the normal and the tumor parent can be distinguished cytogenetically. Highly tumorigenic, in vitro maintained hybrids, and high-tumorigenic segregants of originally low-tumorigenic in vitro hybrids, selected by in vivo passage, showed a similar cytogenetic pattern. It was characterized by the amplification of the tumor-derived chromosomes No. 15 from the expected 3 to 5.5 +/- 0.2 copies and a concomitant decrease of the normal derived T(14;15)6 from 2 copies to 0.9 +/- 0.2. All other autosomes except No. 14 showed only minor random variations, around the expected number of 4 copies. The tumor-derived chromosome 14 was amplified from the expected 2 to 3 copies. The low-tumorigenic hybrids showed the opposite pattern with a decrease in the number of the tumor-derived 15 chromosome from 3 to 2.6 +/- 0.1 and the maintenance of the two normal parent derived T(14;15)6 chromosomes. These findings suggest th...Continue Reading

References

Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J SpiraG Klein
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Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein

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Citations

Jan 1, 1984·Cancer Metastasis Reviews·L Larizza, V Schirrmacher
Mar 1, 1986·Human Genetics·H Hameister, S Adolph
Jun 1, 1983·Cancer Genetics and Cytogenetics·S S BoggsD F Saxe
Dec 1, 1984·Cancer Genetics and Cytogenetics·E Gödde-Salz, E W Schwarze
Sep 1, 1993·Cancer Genetics and Cytogenetics·R DofukuJ Hilgers
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M AdamsS Cory
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J J HarrisonR Sager
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I R van DrielJ W Goding
Jun 18, 1985·European Journal of Biochemistry·I R van Driel, J W Goding
Mar 15, 1990·International Journal of Cancer. Journal International Du Cancer·K Kubota, H Katoh
Jan 1, 1985·Leukemia Research·M O DiazJ D Rowley
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·G ReinholdssonT Dalianis
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·F CarbonellL Kreja
Oct 15, 1984·International Journal of Cancer. Journal International Du Cancer·J E MortenA Busuttil
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·Z WirschubskyJ Sumegi
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·R SzigetiG Klein
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·T RamqvistT Dalianis
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·S SilvaG Klein
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·R SzigetiG Magnusson
Jan 1, 1984·Journal of Cellular Physiology. Supplement·N C CacciaG Klein
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·Z WirschubskyG Klein
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·R DzarlievaN F Fusenig
Jul 1, 1988·Journal of Oral Pathology·N M Boyd, P C Reade
May 16, 1985·Nature·G Klein, E Klein
Feb 15, 1987·International Journal of Cancer. Journal International Du Cancer·I ErnbergM Hansson

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