PMID: 7513028Apr 1, 1994Paper

The role of circulating cells in the healing of vascular prostheses

Journal of Vascular Surgery
S M ScottE T Ahl

Abstract

Cells covering the flow surface of vascular prostheses are derived in part from endothelium of adjacent native artery and from capillaries that extend through the pores of the graft. This study is designed to determine whether these endothelial-like cells can also originate from circulating blood cells and if so to identify them with protein markers. Pledgets of vascular graft material were suspended within the aortas of dogs with metal stents that isolated the pledgets from the aortic wall. Explanted pledgets were examined for cells containing factor VIII-related antigen and other markers identified with monoclonal antibodies. A monolayer of cells that stained positive for factor VIII formed on pledgets after 7 days. Pledgets removed after 55 days had endothelial cells, smooth muscle cells, macrophages, monocytes, and capillary-like structures which were identified by staining for the monoclonal antibodies 43 beta E3 (vimentin), HHF35 (alpha and gamma muscle actin), CGA7 (smooth muscle actin), and HAM56 (macrophage). Woven and knitted polyester and extruded polytetrafluoroethylene pledgets healed in a similar manner. The origin of the cells identified is speculative but they appear to have been derived from circulating cells, ...Continue Reading

Citations

Jan 19, 2000·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·A W LambertM Horrocks
Sep 4, 1999·The Annals of Thoracic Surgery·R HouelD Y Loisance
Feb 26, 2009·Cytotherapy·Julie A MundJamie Case
Oct 13, 2011·Journal of Cellular Physiology·Rupadevi MuthaianAkshay Anand
Apr 1, 1997·Journal of Vascular Surgery·Q ShiL R Sauvage
May 1, 1995·Journal of Vascular Surgery·M H WuL R Sauvage
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Tsukasa OzawaRen-Ke Li
Nov 27, 2004·Current Topics in Developmental Biology·Gina C Schatteman
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frank A Scappaticci
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Gina C Schatteman, Ola Awad
Nov 28, 2001·British Journal of Haematology·N QuiriciG L Deliliers
May 2, 2002·Journal of Hematotherapy & Stem Cell Research·Adrian J C BloorBerthold Göttgens
May 22, 2004·Stem Cells·Matilde MurgaGiovanna Tosato
Aug 23, 2000·The Journal of Clinical Investigation·G C SchattemanB A Christy
Jan 5, 2000·The Journal of Clinical Investigation·Y LinR P Hebbel
May 31, 2008·Expert Review of Cardiovascular Therapy·Glenn Marsboom, Stefan Janssens
Feb 16, 2000·Investigative Radiology·S Müller-HülsbeckM Heller
Jan 25, 2002·Annals of the New York Academy of Sciences·J H CampbellG R Campbell
Nov 23, 2006·Leukemia Research·Domenico Ribatti
Aug 19, 2021·Journal of the Royal Society, Interface·Duy T NguyenJuan M Jiménez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.