The role of clinically significant venous thromboembolism and thromboprophylaxis in pediatric patients with pelvic or femoral fractures

Journal of Pediatric Orthopedics
Lark J GreenwaldMichael C Ain

Abstract

In adults, pelvic and femoral fractures have a known association with venous thromboembolic disease and, thus, thromboprophylaxis is the standard of care. However, similar data for children are scarce, and recommendations for pediatric prophylaxis are less clear. Our goals were to: (1) analyze the predisposing risk factors, prevalence, and outcome (including mortality) of clinically significant venous thromboembolism; (2) investigate the use of thromboprophylaxis in pediatric trauma patients and ages at which it was given; and (3) determine the impact that central venous catheters had on the occurrence of venous thromboembolism. We reviewed the records of all pediatric patients with pelvic or femoral fracture admitted to our hospital from 1990 through 2009 for occurrence of venous thromboembolism and related mortality, use and effect of central venous catheters, use of thromboprophylaxis (heparin, warfarin, enoxaparin, or factor-X inhibitors), and patient age at administration. Of the 1782 patients, 948 had electronically searchable medication (and device) records. Ninety-five percent confidence intervals were found for all proportions with sample sizes >100, and an unpaired t test was used to compare the average age at which t...Continue Reading

References

Jun 1, 1990·The Journal of Trauma·K F O'Malley, S E Ross
Jul 1, 1986·Journal of Pediatric Surgery·L T NguyenD Albert
Jun 1, 1981·Journal of Pediatric Surgery·J R BuckA G Coran
Jul 1, 1996·American Journal of Surgery·L D BrittA Minghini
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A K ChanP M Massicotte
Jan 19, 2006·Circulation·Sudha Parasuraman, Samuel Z Goldhaber
Jun 20, 2008·British Journal of Haematology·Tina T BissSuzan Williams
Nov 14, 2008·Pediatric Radiology·Teresa VictoriaSandra S Kramer
Jan 20, 2009·Heart & Lung : the Journal of Critical Care·Betul TavilAytemiz Gurgey
Apr 22, 2009·AJR. American Journal of Roentgenology·Supika KritsaneepaiboonPhillip M Boiselle
Aug 18, 2009·Journal of Thrombosis and Haemostasis : JTH·T T BissS Williams
Jan 1, 2010·Thrombosis·Isis S R CarterRoss T A Macgillivray

❮ Previous
Next ❯

Citations

Jul 13, 2013·Journal of Pediatric Surgery·A Jill ThompsonChristian J Streck
Oct 16, 2015·Journal of Children's Orthopaedics·Robert F MurphyBenjamin J Shore
Apr 24, 2014·Journal of Pediatric Orthopedics. Part B·Seung-Ju Kim, Sanjeev Sabharwal
Jul 11, 2014·Spine·Amit JainPaul D Sponseller
Jan 10, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Henry Bone EllisPhilip L Wilson
Mar 11, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jennifer YenClifford M Takemoto
Mar 30, 2017·Frontiers in Pediatrics·Ranjit S Chima, Sheila J Hanson
Oct 5, 2017·Frontiers in Pediatrics·Char M Witmer, Clifford M Takemoto
Jan 20, 2021·Pediatric Surgery International·Christina GeorgeadesDavid Gourlay
Dec 21, 2019·Orthopaedics & Traumatology, Surgery & Research : OTSR·Thierry OdentYves Gruel
Jul 28, 2020·Journal of Pediatric Surgery·Sheila J HansonE Vincent S Faustino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses
Sarah H O'BrienMazen S Zenati
Journal of Pediatric Surgery
Anne K TruittFrancois I Luks
Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses
Sarah H O'BrienBarbara A Gaines
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Sean D CandrilliSarah H O'Brien
© 2021 Meta ULC. All rights reserved