The Role of CNS in the Effects of Salt on Blood Pressure

Current Hypertension Reports
Megumi Fujita, Toshiro Fujita

Abstract

Sympathetic nerve activity is involved in the pathogenesis of salt-sensitive hypertension. The central nervous system, which regulates sympathetic nerve activity and blood pressure, plays a pivotal role. Central sympathoexcitation is deeply involved in the pathogenesis of salt-sensitive hypertension, although the precise mechanisms have not been fully elucidated because of their complexity. The role of brain oxidative stress in sympathoexcitation has been suggested in some types of hypertensive animal models. We have shown that increased brain oxidative stress may elevate arterial pressure through central sympathoexcitation in salt-sensitive hypertension. Several other factors such as mineralocorticoid receptors, aldosterone, corticosterone, epithelial sodium channels, and angiotensin II also play important roles in central sympathetic activation, some of which can be associated with brain oxidative stress. Furthermore, brain paraventricular nucleus Gαi2-protein-mediated transduction has been recently reported as a candidate for the molecular mechanism countering the development of salt-sensitive hypertension.

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Citations

Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiao-Qing DingZhi-Ren Zhang
Apr 30, 2017·Current Hypertension Reports·Masha Prager-KhoutorskyCharles W Bourque
Feb 16, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ningning WanAkira Nishiyama
Dec 13, 2016·Heart Failure Reviews·Milla Marques HermidorffMauro César Isoldi
Apr 27, 2017·Current Hypertension Reports·Elaine M RichardsSeungbum Kim
Mar 18, 2021·Cell Reports·David I LeviCharles W Bourque

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