The Role of Combined Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI for Differentiating Malignant From Benign Breast Lesions Presenting Washout Curve.

Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
Sehnaz TezcanEda Yilmaz Akcay

Abstract

The aim of this study is to evaluate the diagnostic performance of combined breast magnetic resonance imaging (MRI) protocol including dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in patients with enhancing lesions that demonstrated washout curve and to determine whether applying apparent diffusion coefficient (ADC) cutoff value could improve the diagnostic value of breast MRI. The retrospective study included 116 patients with 116 suspicious breast lesions, which showed washout curve on DCE-MRI, who underwent subsequent biopsy. Morphologic characteristics on DCE-MRI and ADC values on DWI were evaluated. Apparent diffusion coefficient values and morphologic features of benign and malignant lesions were compared. Diagnostic values of DCE-MRI and combined MRI, including DCE-MRI and DWI (applying an ADC cutoff value) for distinguishing malignancy from benign lesions, were calculated. Of the 116 breast lesions, 79 were malignant and 37 were benign. The ADC value of malignant tumors (median ADC, 0.72 × 10-3 mm2/s) was significantly lower than that of benign lesions (median ADC, 1.03 × 10-3 mm2/s; P < .000). The sensitivity and specificity of an ADC cutoff value of 0.89 × 10-3 mm2/s were 92% and 95%, r...Continue Reading

References

Apr 27, 2001·Radiology·L W NunesS G Orel
Oct 28, 2003·Topics in Magnetic Resonance Imaging : TMRI·Caroline Reinhold
Dec 9, 2004·JAMA : the Journal of the American Medical Association·David A BluemkeMitchell D Schnall
Dec 24, 2005·Radiology·Mitchell D SchnallConstantine A Gatsonis
Aug 10, 2006·Journal of Magnetic Resonance Imaging : JMRI·Denis Le BihanFranck Lethimonnier
Nov 26, 2009·AJR. American Journal of Roentgenology·Savannah C PartridgeConstance D Lehman
May 25, 2010·Magnetic Resonance Imaging Clinics of North America·Virginia Molleran, Mary C Mahoney
Dec 24, 2010·AJR. American Journal of Roentgenology·Sibel KulAbdulkadir Reis
May 19, 2011·Journal of Magnetic Resonance Imaging : JMRI·Sanaz A JansenGillian M Newstead
Jul 20, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Reiko WoodhamsYusuke Inoue
Sep 21, 2011·The Breast Journal·Hanaa A T Al-KhawariOmolara Roberts
Dec 3, 2014·Clinical Imaging·Yazmín Aseret Ramírez-GalvánGuillermo Elizondo-Riojas
Apr 29, 2015·Journal of Magnetic Resonance Imaging : JMRI·Maarten W BarentszBruce L Daniel
Apr 30, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Eun Kyung ParkJeoung Won Bae
Jul 28, 2016·Breast Cancer Research : BCR·Shandong WuJules H Sumkin
Oct 1, 2016·Journal of Magnetic Resonance Imaging : JMRI·Savannah C PartridgeEric E Sigmund

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