The Role of Contactin 1 in Cancers: What We Know So Far

Frontiers in Oncology
Yumei LiangHaining Zhang

Abstract

Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CNTN1 is a neuronal membrane glycoprotein, which, if overexpressed, is found in different cancer cell lines, cancer tissues, and transgenic mice. It is positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time. However, the role of CNTN1 in cancer cell proliferation remains unclear. In addition, CNTN1 is involved in cancer cell invasion, migration, metastasis, and chemoresistance by promoting epithelial-mesenchymal transition and mediating several signal transduction pathways. Several studies suggest CNTN1 as a new therapeutic target for cancers. This review aims to summarize the research developments on CNTN1 in various cancers, to establish its role in epithelial-mesenchymal transition and signal transduction pathways, and to identify promising areas for further investigation.

References

Jul 29, 2003·Cell and Tissue Research·Michael S PepperMihaela Skobe
Mar 15, 2006·Cancer Cell·Jen-Liang SuMin-Liang Kuo
Jun 4, 2008·Annals of the New York Academy of Sciences·Marc G Achen, Steven A Stacker
Mar 24, 2009·Neuro-oncology·Helena NordTeresita Díaz de Ståhl
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim CzopkaAndreas Faissner
Mar 18, 2011·Experimental Dermatology·Andreas MauererThomas Vogt
Mar 1, 2012·Developmental Biology·Antonella BizzocaGianfranco Gennarini
Apr 23, 2013·Gastroenterology Research and Practice·Ji-Wei YuBo-Jian Jiang
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Samy LamouilleRik Derynck
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yong-Chao LiuGuang-Jian Huang
Feb 11, 2015·Neurobiology of Aging·Daniela PuzzoAgostino Palmeri
Mar 27, 2015·Brain : a Journal of Neurology·Yumako MiuraUNKNOWN CNTN1-CIDP Study Group
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ruijie ZhangJianping Xu
Feb 2, 2016·Journal of Clinical Medicine·Bethany N Smith, Neil A Bhowmick
Feb 9, 2016·OncoTargets and Therapy·Guang-Yao LiWei-Dong Jia
Jul 15, 2017·Nature Reviews. Neurology·Luis QuerolIsabel Illa
Sep 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ruijie ZhangPei Li
Mar 23, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steffen DettlingChristel Herold-Mende
May 16, 2018·Annals of Clinical and Translational Neurology·Ana M SilesLuis Querol
Jan 11, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Madhurima ChatterjeeCharlotte E Teunissen
Jun 30, 2019·Alzheimer's Research & Therapy·Cristina M Pedrero-PrietoJuan R Peinado

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Citations

Apr 4, 2021·Biomolecules·Yan GuDamu Tang

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Methods Mentioned

BETA
xenograft
nucleotide exchange
immunoprecipitation

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