PMID: 9554173Apr 29, 1998Paper

The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy

Diagnostic Microbiology and Infectious Disease
S F KozakA A Sadun

Abstract

The principal side effect of the antimycobacterial agent ethambutol (EMB) is an optic neuropathy with clinical features very similar to a mitochondrial hereditary optic neuropathy (Leber's). The mechanism of EMB-induced optic neuropathy may be EMB's chelation of copper, thereby precluding normal cytochrome c oxidase activity and mitochondrial metabolism in the optic nerve. Before attempting to use therapeutic copper to replenish endogenous stores in an attempt to preclude EMB-induced optic neuropathy, we wished to determine whether EMB is still effective against mycobacteria in the presence of copper. EMB and copper, alone and in combination, were tested against six strains of Mycobacterium tuberculosis and five strains of Mycobacterium avium using a radiometric broth macrodilution assay. Copper did not effect EMB's antimicrobial actions against either species of mycobacteria. This in vitro study suggests that if copper were given to patients to prevent EMB-induced optic neuropathy, it would not compromise EMB's bacteriostatic properties.

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Citations

Feb 5, 2009·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Richard J Church, Edward W Boyer
Nov 27, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christopher I ZoumalanAlfredo A Sadun
Feb 19, 2002·Neurochemistry International·Valerio CarelliAlfredo A Sadun
Jan 16, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Eun Ji LeeYoung Suk Yu
May 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Michelle Y Wang, Alfredo A Sadun
Jan 11, 2007·Drugs·Ricardo M Santaella, Frederick W Fraunfelder
Apr 30, 2016·Neural Regeneration Research·Chun-Xia PengShi-Hui Wei
Jul 19, 2012·Expert Opinion on Drug Metabolism & Toxicology·Mitan R GokulgandhiAshim K Mitra
Aug 16, 2006·Expert Opinion on Drug Safety·Frederick W FraunfelderTerry Wood
Sep 1, 2007·Seminars in Ophthalmology·Setareh VistamehrRon A Adelman
Jan 4, 2017·Journal of Optometry·Yasmine L PilzJerome Sherman
Jul 25, 2018·Current Eye Research·Jeffrey J YuChantal J Boisvert
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Junping LiBrenda J Tripathi
Aug 2, 2017·Current Opinion in Ophthalmology·Paul D ChamberlainAndrew G Lee
Sep 17, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Marc A BouffardNurhan Torun
Oct 5, 2019·Continuum : Lifelong Learning in Neurology·Cristiano Oliveira
Oct 18, 2008·Clinical & Experimental Ophthalmology·Janet K KimAlfredo A Sadun
Dec 12, 2020·Scientific Reports·Yung-Ju YooHee Kyung Yang

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