The role of Cortistatin-14 in the gastrointestinal motility in mice

Pharmacological Reports : PR
JinHong JiangMin Chang

Abstract

This study aimed to investigate the functional roles of Cortistatin-14 (CST-14) in the gastrointestinal (GI) motility. For in vivo study, mice were randomly divided into control, ip injected CST-14 (0.1, 0.5, 1, 5, 10mg/kg)+control group, icv injected CST-14 (5μg)+control group, dextran sulfate sodium-induced colitis group, CST-14+colitis group, castor oil-induced diarrhea group, CST-14+diarrhea group. We carried out these experiments by quantitative real-time PCR, GI transit, bead expulsion and fecal pellet output. For in vitro study, effects of CST-14 were investigated in the longitudinal and circular muscle contractions of jejum, ileum, and colon. In vivo, the expression of CST-14 mRNA was significantly decreased in the colon of colitis mice and CST-14 significantly inhibited GI transit rate in colitis mice, and delayed the emergence of liquid feces in castor oil-induced diarrhea mouse model. Additionally, ip injection of CST-14, but not icv injected, remarkably inhibited GI transit, bead expulsion and fecal pellet output in mice. In vitro assays, CST-14 (10-6M) could relax the rhythms of the longitudinal muscles and circular muscles of the jejunum, ileum and colon of mice. The further study indicated that the roles of CST-1...Continue Reading

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Citations

Feb 26, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Loyane Almeida GamaMadileine Francely Américo
Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhe WangMin Chang
May 5, 2020·Canadian Journal of Physiology and Pharmacology·Jing ZhangShouliang Dong
Jun 11, 2021·The Journal of Allergy and Clinical Immunology·Karthi DuraisamyBilly K C Chow

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