PMID: 8597448Dec 29, 1995Paper

The role of CRF in behavioral aspects of stress

Annals of the New York Academy of Sciences
S C HeinrichsG F Koob

Abstract

CRF in the central nervous system appears to hve activating properties on behavior and to coordinate behavioral responses to stressors. These behavioral effects of CRF appear to be independent of the pituitary-adrenal axis and can be reversed by CRF antagonists. CRF antagonist administration reverses not only decreases in behavior associated with stress, but also increases in behavior associated with stress, thus suggesting that the role of CRF is stress dependent and not intrinsic to a given behavioral response. Further, microinjection of alpha-helical CRF 9-41 and immunotargeting of CRF neurons in separate brain compartments reveal a link between the anatomical sites that contain CRF and the nature of the behavioral response to stressors that can be modified by suppression of endogenous CRF activity therein. These actions of CRF in coordinating coping responses to stress at several bodily levels are consistent with a role for CRF similar to the dual role of other hypothalamic releasing factors in integrating hormonal and neural mechanisms by acting both as secretagogues for anterior pituitary hormones and as extrapituitary peptide neurotransmitters. Moreover, dysfunction in such a fundamental homeostatic system may be the key...Continue Reading

References

Dec 1, 1979·Psychosomatic Medicine·S R Burchfield
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·S C HeinrichsG F Koob
Nov 22, 1991·Science·I Pastan, D FitzGerald
Jan 1, 1991·Psychopharmacology·H A BaldwinK T Britton
Sep 1, 1986·Brain Research Bulletin·D D KrahnA S Levine
Apr 1, 1987·Pharmacology, Biochemistry, and Behavior·J E Sherman, N H Kalin
Jan 1, 1987·Journal of Neuroimmunology·N Schupf, C A Williams
Aug 1, 1971·Journal of Psychiatric Research·J W Mason
Jul 1, 1984·Molecular Immunology·E R Podack, J Tschopp
Nov 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S C HeinrichsG F Koob

❮ Previous
Next ❯

Citations

Nov 25, 2000·Depression and Anxiety·A P MartinsF S Guimarães
Oct 31, 2002·Human Psychopharmacology·I. Hindmarch
Aug 2, 2008·Psychopharmacology·Z MeraliH Anisman
Mar 24, 2004·Neuroscience and Biobehavioral Reviews·M A MorganD W Pfaff
Feb 26, 2003·European Journal of Pharmacology·S Mechiel Korte, Sietse F De Boer
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·P J Kenny, A Markou
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·S M Korte
Feb 21, 2002·Behavioural Brain Research·M A Morgan, D W Pfaff
Jan 23, 1998·Peptides·H KlemfussK T Britton
Dec 15, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H CohenM Kotler
Apr 12, 2003·Pharmacology & Toxicology·Susan RotzingerFranco J Vaccarino
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C WeningerJ A Majzoub
Aug 15, 2006·Annual Review of Psychology·Megan Gunnar, Karina Quevedo
Feb 19, 2011·Journal of Allergy·L MirottiM Russo
Dec 15, 2006·BMC Evolutionary Biology·João C R CardosoDeborah M Power
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Autumn S IvyTallie Z Baram
Jan 30, 2014·Hormones and Behavior·Jéssica E VicentiniMilena B Viana
Feb 18, 2012·Neurobiology of Aging·Qinxi GuoNicholas John Justice
Mar 1, 2012·The Psychiatric Clinics of North America·Radu V Saveanu, Charles B Nemeroff
Jun 24, 2009·Neuroscience and Biobehavioral Reviews·Kim G C HellemansJoanne Weinberg
Aug 15, 2015·Neuroscience and Biobehavioral Reviews·R Parrish WatersCliff H Summers
Sep 24, 2010·Developmental Psychobiology·Aniko Korosi, Tallie Z Baram
Jun 16, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A StengelY Taché
Mar 18, 2005·Comptes rendus biologies·Jan M Deussing, Wolfgang Wurst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.