The role of cystatin C as a biomarker for prognosis in pulmonary arterial hypertension due to congenital heart disease

International Journal of Cardiology
Ilja M BlokBerto J Bouma

Abstract

Adults with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) have a poor prognosis. Identifying patients with a high risk for clinical events and death is important because their prognosis can be improved by intensifying their treatment. Cystatin C, a novel cardiac biomarker, correlates with right ventricular dimensions in patients with idiopathic PAH, giving it potential to determine prognosis in PAH-CHD patients. We investigated the predictive value of cystatin C for long-term mortality and clinical events. Fifty-nine PAH-CHD patients (mean age 42 SD 13 years, 42% male) were included in this prospective observational study, with cystatin C measurements between 2005 and 2015 on the outpatient clinic. Patients were evaluated with a standardized evaluation protocol including laboratory, functional and echocardiographic variables. Clinical events comprised worsening functional classification, worsening heart failure, symptomatic hyperviscosity, haemoptysis and arrhythmia. We used Cox regression to determine predictors for mortality and clinical events. Mean follow-up was 4.4years, during which 12 (20%) patients died. Cystatin C (HR 1.3, p<0.001), creatinine (HR 1.2, p<0.001), NT-pro-BNP (HR 2.0, p=0.012),...Continue Reading

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Citations

Mar 31, 2017·Journal of Clinical Medicine·Alexandra C van DisselBerto J Bouma
May 26, 2017·European Journal of Preventive Cardiology·Carianne L VerheugtBarbara Jm Mulder
Mar 8, 2018·Heart Failure Reviews·Michele CorrealeUNKNOWN Master Program Students on Drug Development for Heart Failure
Mar 18, 2017·Circulation Research·Berto J Bouma, Barbara J M Mulder
Jul 2, 2019·Circulation·Jack RychikUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young and Council on Cardiovascular and Stroke Nursing
Apr 23, 2017·Current Cardiology Reports·Saurabh RajpalAlexander R Opotowsky
Nov 19, 2020·The Journal of International Medical Research·Yang Zi-YangZhang Caojin
Oct 7, 2020·American Journal of Respiratory and Critical Care Medicine·Jason HongXia Yang

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