The role of cytokine polymorphisms in rejection after solid organ transplantation

Genes and Immunity
S E Marshall, K I Welsh

Abstract

The importance of cytokines to the immune response is irrefutable. Their role in the biology of solid organ transplantation per se is also assured. Thus it is likely that subtle differences in cytokine composition, particularly at the initiation of an immune response, may have a major effect on the outcome of that response. This may be particularly relevant in solid organ transplantation, where it is possible that genetic polymorphisms which influence cytokine production may determine the outcome of a transplant. Indeed, it has been suggested that immunosuppression may be individualised on the basis of recipient or donor genotype. However, much of the early data regarding the importance of specific cytokine polymorphisms has not been reproduced, and the significance of this field remains controversial. Nonetheless, with the experience gained from earlier studies, some clear patterns for future studies are emerging.

References

Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Oct 6, 1997·Transplantation·D TurnerI V Hutchinson
Dec 11, 1997·The New England Journal of Medicine·G K HersheyT A Chatila
Sep 2, 1998·Current Opinion in Immunology·F AltareJ L Casanova
Dec 29, 1998·Transplantation Proceedings·I V HutchinsonP Sinnott
Jan 15, 1999·Human Molecular Genetics·D J GraingerT D Spector
May 13, 1999·Nature Genetics
Jun 1, 1999·JAMA : the Journal of the American Medical Association·S T BogardusA R Feinstein
Jul 20, 1999·Kidney International·D SankaranI V Hutchinson
Jul 27, 1999·Proceedings of the Association of American Physicians·J C Knight, D Kwiatkowski
Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A N AbdallahA Iron
Dec 11, 1999·Immunity·R CallardJ Stark
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Jun 27, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C G DensemN H Brooks
Oct 12, 2000·The New England Journal of Medicine·S K TakemotoJ M Cecka
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
May 31, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R J AllcockP Price
Jun 19, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M R AwadA Zeevi

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Citations

Jun 27, 2003·Transplantation Proceedings·A MorgunM Gerbase-DeLima
Feb 25, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard A MorganSteven A Rosenberg
Jul 17, 2004·Transplantation·Lars G WramnerLeonid Padyukov
Dec 23, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Santiago G MiriukaDavid E C Cole
Mar 12, 2010·American Journal of Pharmaceutical Education·Martin M Zdanowicz
Oct 31, 2013·Expert Review of Clinical Immunology·Mohammad H KarimiAli A Pourfathollah
Mar 14, 2013·Transplant Immunology·B Sean CareyEdward R Kaminski
May 1, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Josep GrinyóLaurent Essioux
Jan 31, 2006·Tissue Antigens·L A MarínM R Alvarez-López
Feb 20, 2007·Transplant Immunology·George V MazariegosAmadeo Marcos
Jul 15, 2015·Clinical Biochemistry·Jana StojanovaNicolas Picard
Apr 6, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Grecia M Marrón-LiñaresManuel Hermida-Prieto
May 11, 2005·World Journal of Gastroenterology : WJG·Lie-Ying FanRen-Qian Zhong
Dec 7, 2010·Molecular Biology Reports·Mohammad Hossein KarimiShahram Bolandparvaz
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marit SaethreTom E Mollnes

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