PMID: 11329943May 2, 2001Paper

The role of cytokines in the pathogenesis of diabetic retinopathy

Nippon Ganka Gakkai zasshi
K OharaH Yamashita

Abstract

To investigate the role of cytokines and advanced glycation end products(AGEs) in the pathogenesis of diabetic retinopathy, we measured vascular endothelial growth factor(VEGF), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-alpha), transforming growth factor-beta 1(TGF-beta 1), and pentosidine(an AGE) levels in aqueous, vitreous, and paired plasma obtained from diabetic patients. The aqueous levels of VEGF and IL-6 were positively correlated with the grade of clinical severity of diabetic retinopathy (both VEGF and IL-6, p < 0.001). Other cytokines and pentosidine levels were not significantly associated. The aqueous levels of VEGF and IL-6 were higher than the plasma levels(VEGF p = 0.02, IL-6 p < 0.001). Within the intraocular area VEGF and IL-6 are produced and participate in the pathogenesis of hyperpermeability of retinal vessels in preproliferative diabetic retinopathy.

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