The role of cytokines in the pathogenesis of acute pancreatitis

American Journal of Surgery
J G Norman

Abstract

The systemic manifestations of acute pancreatitis are responsible for the majority of pancreatitis-associated morbidity and mortality and are now believed to be due to the actions of specific inflammatory cytokines. This report summarizes what is known about the role of cytokines in the pathogenesis of acute pancreatitis. Comprehensive literature review of experimental pancreatitis as well as all reports of cytokine involvement during clinical pancreatitis. Several cytokines and other noncytokine inflammatory mediators are produced rapidly during pancreatitis. These mediators arise in many tissues in a predictable fashion independent of the animal model used or the underlying etiology in human disease. Preventing the activities of these mediators has a profound beneficial effect in experimental animals. A few recently described inflammatory mediators are believed to be primarily responsible for the systemic manifestations of acute pancreatitis and its associated distant organ dysfunction. The predictable nature in which they are produced may allow for novel approaches to treating this disease. Am J Surg.

References

May 1, 1978·Annals of Surgery·J H Ranson, F C Spencer
Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·R SeeligH P Seelig
Nov 1, 1992·Archives of Surgery·M L Steer
Jan 1, 1991·Pancreas·J R Bettinger, J H Grendell
Apr 28, 1994·The New England Journal of Medicine·W Steinberg, S Tenner
Dec 1, 1993·Irish Journal of Medical Science·T A CreaghP J Broe

❮ Previous
Next ❯

Citations

Nov 3, 2004·The British Journal of Surgery·P MentulaH Repo
Apr 1, 2009·Journal of Hepato-biliary-pancreatic Surgery·Bulent Hamdi UcanMustafa Comert
Jul 27, 2006·Journal of Gastroenterology·Hidehiro SawaYoshikazu Kuroda
Oct 12, 2012·Apoptosis : an International Journal on Programmed Cell Death·Gang WangBei Sun
Sep 1, 2005·Inflammation·Etem AlhanBirgul Vanizor Kural
Jul 27, 2007·Inflammation·Serdar TurkyilmazBirgul Kural Vanizor
Sep 16, 2010·Inflammation·ZhiMin LiuJing Yang
Jun 3, 2011·Inflammation·Zhiqiang ZhangQi Dong
Jul 31, 2013·Inflammation·Arif Burak CekicCengiz Erçin
Jul 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mehrdad NikfarjamChristopher Christophi
Mar 29, 2001·Current Gastroenterology Reports·B GloorM W Büchler
Jul 13, 2004·Current Gastroenterology Reports·Neeraj Kaushik, Stephen J D O'Keefe
Feb 15, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·K Sri ManjariA Venkateshwari
Mar 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G CavalliniUNKNOWN ProInf-AISP Study Group
May 17, 2005·The Journal of Surgical Research·Linda C Vona-DavisDavid W McFadden
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ahmet GulcubukKenan Ates
Jun 25, 2004·Experimental and Molecular Pathology·Stanisław HaćRobert Rzepko
Sep 2, 1999·The Surgical Clinics of North America·S Karne, F S Gorelick
Sep 2, 1999·The Surgical Clinics of North America·W Denham, J Norman
Sep 2, 1999·The Surgical Clinics of North America·H G Beger, R Isenmann
Jan 11, 2000·Veterinary Immunology and Immunopathology·C G RuauxR B Atwell
Apr 17, 2003·Revista de gastroenterología de México
May 22, 2002·Surgical Oncology·Buckminster Farrow, B Mark Evers
Jun 26, 2002·Journal of the American College of Surgeons·Eric S HungnessFred A Luchette
Oct 12, 2002·Journal of the American College of Surgeons·Richard T EthridgeB Mark Evers
Dec 24, 2002·Journal of the American College of Surgeons·Thomas J Howard, Michael B Temple
Feb 19, 1999·Journal of the American College of Surgeons·T A Bowden
Nov 5, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shiro WatanabeYutaka Aoyagi
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Myriam DelhayeJacques Devière
Sep 12, 2000·Acta Anaesthesiologica Scandinavica·A R HellerT Koch
Jul 10, 2001·The British Journal of Surgery·B GloorM W Büchler
Jun 10, 2000·The British Journal of Surgery·D N LoboB J Rowlands
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S AggarwalA L Gurney
Jul 7, 2011·Antioxidants & Redox Signaling·Minoti ApteJeremy Wilson
Sep 20, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Praveen RavishankaranRavindra Bhat
Mar 27, 2007·Surgical Infections·Tercio De CamposRaul Coimbra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.