The role of danger signals and ectonucleotidases in acute graft-versus-host disease

Human Immunology
Petya Apostolova, Robert Zeiser

Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) represents the only curative treatment approach for many patients with benign or malignant diseases of the hematopoietic system. However, post-transplant morbidity and mortality are significantly increased by the development of acute graft-versus-host disease (GvHD). While alloreactive T cells act as the main cellular mediator of the GvH reaction, recent evidence suggests a critical role of the innate immune system in the early stages of GvHD initiation. Danger-associated molecular patterns released from the intracellular space as well as from the extracellular matrix activate antigen-presenting cells and set pro-inflammatory pathways in motion. This review gives an overview about danger signals representing therapeutic targets with a clinical perspective with a particular focus on extracellular nucleotides and ectonucleotidases.

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Citations

May 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M MattaH R Turnquist
Apr 5, 2017·Frontiers in Immunology·Sakhila GhimireErnst Holler
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Aug 8, 2021·International Journal of Molecular Sciences·Peter CuthbertsonRonald Sluyter
Aug 28, 2021·World Journal of Transplantation·Masayuki Nagasawa

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