PMID: 8967778Mar 1, 1996Paper

The role of dendritic cells in cutaneous immunity

Archives of Dermatological Research
M B LappinM Norval

Abstract

This article reviews the role of dendritic cells in cutaneous immunity. Langerhans cells (LC) found in the epidermis are the best-characterized dendritic cell population. They have the ability to process antigen in the periphery, transport it to the draining lymph nodes (DLN) where they are able to cluster with, and activate, antigen-specific naive T cells. During migration LC undergo phenotypic and functional changes which enable them to perform this function. There are other less well-characterized dendritic cells including dendritic epidermal T cells, dermal dendrocytes and dermal "LC-like' cells. Although there is no evidence that dendritic epidermal T cells (DETC) can present antigen or migrate to lymph nodes, they do influence the intensity of cutaneous immune responses to chemical haptens. Antigen-presenting cells (APC) in the dermis may provide alternative routes of antigen presentation which could be important in the regulation of skin immune responses. Therefore, dendritic cells are vital for the induction of immune responses to antigens encountered via the skin. LC are particularly important in primary immune responses due to their ability to activate naive T cells. The faster kinetics of secondary responses, and the...Continue Reading

References

Sep 1, 1978·The Journal of Investigative Dermatology·J W Streilein
Jul 21, 1977·Nature·G RowdenA K Sullivan
Oct 1, 1992·The Journal of Experimental Medicine·C P LarsenR P Lowry
Jan 1, 1992·Journal of Dermatological Science·S ShimadaK Tamaki
Nov 11, 1992·The Journal of Investigative Dermatology·P R BergstresserA Takashima
Dec 1, 1992·European Journal of Immunology·D J McKeeverW I Morrison
Sep 1, 1992·European Journal of Immunology·C R MackayL Dudler
Nov 1, 1992·The Journal of Investigative Dermatology·A H Enk, S I Katz
Oct 11, 1992·The Journal of Investigative Dermatology·C D BucanaM L Kripke
Nov 1, 1992·The Journal of Investigative Dermatology·T BieberA Wollenberg
Nov 1, 1992·The Journal of Investigative Dermatology·M J StaquetD Schmitt
Nov 1, 1992·The Journal of Investigative Dermatology·I Kimber, M Cumberbatch
Sep 1, 1990·Scandinavian Journal of Immunology·O BaadsgaardG Lange-Vejlsgaard
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Aug 2, 1990·Nature·T A Springer
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S Freudenthal, R M Steinman
Jan 1, 1990·International Reviews of Immunology·R AggerM D Witmer-Pack
Feb 1, 1990·The British Journal of Dermatology·G De PanfilisA Zucchi
Dec 1, 1989·Immunology Today·M W MakgobaS Shaw
Mar 1, 1989·Reviews of Infectious Diseases·M A Beilke
Nov 1, 1989·The Journal of Investigative Dermatology·N RomaniG Schuler
Oct 1, 1989·The British Journal of Dermatology·R CerioJ T Headington
Jan 1, 1989·International Archives of Allergy and Applied Immunology·A KinnairdI Kimber
Oct 1, 1989·The Journal of Experimental Medicine·R BujdosoI McConnell
Feb 1, 1986·The Journal of Experimental Medicine·K Inaba, R M Steinman
Apr 1, 1986·The Journal of Investigative Dermatology·K D CooperS I Katz

❮ Previous
Next ❯

Citations

Nov 28, 2007·Cell and Tissue Research·Tomoatsu KanekoHideaki Suda
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Kristian ReichAxel Schnuch
Oct 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K ReutterU Hoppe
Mar 29, 2000·The British Journal of Dermatology·I KimberC E Griffiths
May 8, 1999·Immunology·D M HaigH R Miller
Dec 12, 2001·International Journal of Dermatology·J Abulafia, R A Vignale
Oct 19, 2004·Clinical Microbiology Reviews·Louis de RepentignyPaul Jolicoeur
Oct 8, 2005·Expert Review of Proteomics·Chun-Ming HuangCraig A Elmets
Aug 29, 2003·Expert Opinion on Biological Therapy·Charalambos D Partidos
Jul 9, 2011·Cutaneous and Ocular Toxicology·Sandra BelijMilena Kataranovski
Dec 15, 2007·Immunology Letters·Timoleon PapagatsiasSteven Patterson
Oct 2, 2007·Dermatologic Clinics·Flávio Barbosa LuzMarcia Ramos-e-Silva
Dec 7, 2006·International Review of Cytology·G I BechanR J Arceci
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M P V ChiossiA M F Roselino
Sep 18, 2004·Mass Spectrometry Reviews·Chun-Ming HuangDe-Chu C Tang
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·I Kimber, R J Dearman
Jul 31, 2003·Nature Immunology·Andrea A Itano, Marc K Jenkins
Jun 15, 2007·The Journal of Primary Prevention·Martha R BurtAnn Elizabeth Montgomery
Mar 10, 2001·Clinical and Diagnostic Laboratory Immunology·M ScottA B Moscicki
Aug 29, 2020·International Journal of Laboratory Hematology·Yunzhou WuXiaomeng Lin
Nov 7, 2001·Scandinavian Journal of Immunology·B HasséusU I Dahlgren
May 19, 2000·Annals of the New York Academy of Sciences·L LundebergO Johansson
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanhong DingRichard D Granstein
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristina SeiffertRichard D Granstein
Dec 6, 2003·Journal of Cell Science·Christina FieberJonathan P Sleeman

❮ Previous
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