The role of diabetes on the clinical manifestations of pulmonary tuberculosis

Tropical Medicine & International Health : TM & IH
Daniel Faurholt-JepsenHenrik Friis

Abstract

Diabetes is associated with pulmonary tuberculosis (TB), possibly due to impaired immunity, and diabetes may exacerbate the clinical manifestations of TB. Our aim was to assess the role of diabetes in the clinical manifestations of TB. We studied 1250 patients with pulmonary TB in an urban population in a cross-sectional study in Tanzania. All participants were tested for diabetes and HIV co-infection, and TB culture intensity was assessed. Levels of white blood cells, haemoglobin, acute phase reactants, CD4 count and HIV viral load were measured, and a qualitative morbidity questionnaire was used to identify the prevalence of disease-related symptoms. Tuberculosis patients with diabetes had a higher neutrophil count (B 0.5 × 10(9) cells/l, 95% CI 0.2; 0.9, P = 0.001) than non-diabetic TB patients. Serum C-reactive protein (B 18.8 mg/l, CI 95% 8.2; 29.4, P = 0.001) and alpha-1-acid glycoprotein (B 0.2 g/l, CI 95% 0.03; 0.3, P = 0.02) were similarly higher in patients with diabetes. Diabetes did not affect culture intensity or HIV status, but self-reported fever was three times higher among participants with diabetes than in those without diabetes (OR 2.9, CI 95% 1.5; 5.7, P = 0.002). Diabetes is associated with small changes in...Continue Reading

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Citations

May 9, 2014·Current Diabetes Reports·Marit Eika Jørgensen, Daniel Faurholt-Jepsen
Mar 14, 2014·Scandinavian Journal of Infectious Diseases·Daniel Faurholt-JepsenAse Bengård Andersen
Oct 12, 2013·Tropical Medicine & International Health : TM & IH·A N Murunga, P M O Owira
Apr 2, 2015·European Journal of Clinical Nutrition·G PrayGodH Friis
Apr 23, 2016·Tropical Medicine & International Health : TM & IH·Damiano PizzolAnnalisa Saracino
May 20, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Robert S FotiDan A Rock
May 17, 2019·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Cíntia Vieira Nascimento, Sônia Maria Soares
Jul 13, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Sâmia Barreto LealSusan Martins Pereira
Aug 10, 2018·Current Diabetes Reports·Matthew J MageeGuillermo E Umpierrez

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