The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study

Seminars in Arthritis and Rheumatism
Jos RunhaarSita M A Bierma-Zeinstra

Abstract

The PRevention of knee Osteoarthritis in Overweight Females (PROOF) study (ISRCTN 42823086) described a trend for a decrease in the incidence of knee osteoarthritis (OA) by a tailored diet and exercise program (DEP) or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2×2 factorial design. A total of 407 overweight (BMI ≥ 27kg/m(2)) women of 50-60 years of age with no diagnosis of knee OA were randomized to: (1) no DEP + placebo (Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N =102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500mg once daily, double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of ≥1mm minimum joint space narrowing (mJSN) in the...Continue Reading

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Mar 31, 2015·The American Journal of Medicine·Jos RunhaarSita M A Bierma-Zeinstra
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Citations

Sep 8, 2017·Annals of the Rheumatic Diseases·Jean-Yves L ReginsterCyrus Cooper
Sep 20, 2018·Orthopedics·Jack M BertAnnabelle P Davey
Feb 24, 2021·Diabetes, Obesity & Metabolism·Shohinee SarmaSatya Dash
Mar 29, 2021·Aging Clinical and Experimental Research·Swan Sim YeapEster Penserga
Jul 1, 2021·Aging Clinical and Experimental Research·Zhiyi ZhangHuaihuan Zhang

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