Abstract
1. The effect of varying dietary levels of casein (40-140 g/kg) on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1.1.1.49; G6PD), malic enzyme (EC 1.1.1.40; ME), citrate cleavage enzyme (EC 4.1.3.8; CCE), acetyl CoA carboxylase (EC 6.4.1.2; AcCx), glucokinase (EC 2.7.1.2; GK), and pyruvate dehydrogenase (PDH) was examined in young, growing rats. 2. The activities of AcCx, FAS, G6PD and in vivo fatty acid synthesis were generally found to increase with increased dietary protein. 3. The levels of GK and PDH were not related to dietary protein. 4. ME decreased with increasing dietary protein. 5. The results demonstrate a dissociation between hepatic fatty acid synthesis and ME and suggest that when rats consume low-protein diets the NADPH needed for fatty acid synthesis is generated primarily by ME but that as the level of dietary protein is increased the contribution of ME is reduced while that of the phosphogluconate pathway becomes more important.
References
Apr 1, 1976·Physiological Reviews·J J Volpe, P R Vagelos
Jan 15, 1978·The Biochemical Journal·C D Gove, D A Hems
Dec 1, 1975·The Journal of Nutrition·J PeretI Macaire
Jan 1, 1975·Current Topics in Cellular Regulation·R Frenkel
May 1, 1978·The Journal of Nutrition·J TriscariA C Sullivan
Jul 1, 1977·The Journal of Nutrition·S D ClarkeG A Leveille
Jul 1, 1977·The Journal of Nutrition·S D ClarkeG A Leveille
Aug 1, 1977·The Journal of Nutrition·S D ClarkeG A Leveille
Jan 1, 1975·Archives of Biochemistry and Biophysics·M J StarkR Frenkel
Jan 1, 1975·Methods in Enzymology·S J Pilkis
Dec 18, 1972·Biochemical and Biophysical Research Communications·R FrenkelJ Stafford
Sep 1, 1972·The Biochemical Journal·K R BruckdorferJ Yudkin
Jan 1, 1972·Advances in Enzyme Regulation·D M GibsonY Muto
Apr 16, 1974·Life Sciences·M J Stark, R Frenkel
Jul 26, 1974·Biochimica Et Biophysica Acta·D R Romsos, G A Leveille
Apr 11, 1972·European Journal of Biochemistry·O H WielandG Löffler
Aug 1, 1970·The Journal of Nutrition·Y Y YehJ H Wiley
Jul 1, 1969·The Journal of Nutrition·Y Y Yeh, G A Leveille
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·J GOA
Nov 1, 1960·Biochemical and Biophysical Research Communications·D M GIBSON, D D HUBBARD
May 1, 1964·The American Journal of Physiology·D A VAUGHAN, R L WINDERS
Feb 1, 1965·The Journal of Nutrition·D M Hegsted, Y O Chang
Nov 1, 1946·The Journal of Nutrition·R H BARNESJ E MAACK
Citations
Jun 5, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jorge DiasSadasivam Kaushik
Jun 19, 2001·The International Journal of Biochemistry & Cell Biology·J B BarrosoJ A Lupiáñez
Jul 1, 1984·The British Journal of Nutrition·G R Herzberg, M Rogerson
Jul 26, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Janice S LeeJ Christopher Corton
Jan 22, 2009·Journal of Nutritional Science and Vitaminology·Keiichi Kojima, Michio Kasai
May 6, 2010·Amino Acids·A Cláudia Figueiredo-SilvaLuísa M P Valente
Aug 10, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J DiasS J Kaushik
Oct 12, 2016·Journal of Nutritional Science and Vitaminology·Kazuo EramiMasao Sato
Sep 5, 2001·The Journal of Nutrition·K A Adams, A J Davis
Jun 27, 2001·Medical Hypotheses·M F McCarty