The role of diffusion tensor imaging as an objective tool for the assessment of motor function recovery after paraplegia in a naturally-occurring large animal model of spinal cord injury

Journal of Translational Medicine
A Wang-LeandroA Tipold

Abstract

Traumatic spinal cord injury (SCI) results in sensory and motor function impairment and may cause a substantial social and economic burden. For the implementation of novel treatment strategies, parallel development of objective tools evaluating spinal cord (SC) integrity during motor function recovery (MFR) is needed. Diffusion tensor imaging (DTI) enables in vivo microstructural assessment of SCI. In the current study, temporal evolvement of DTI metrics during MFR were examined; therefore, values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in a population of 17 paraplegic dogs with naturally-occurring acute SCI showing MFR within 4 weeks after surgical decompression and compared to 6 control dogs. MRI scans were performed preoperatively and 12 weeks after MFR was observed. DTI metrics were obtained at the lesion epicentre and one SC segment cranially and caudally. Variance analyses were performed to compare values between evaluated localizations in affected dogs and controls and between time points. Correlations between DTI metrics and clinical scores at follow-up examinations were assessed. Before surgery, FA values at epicentres were higher than caudally (p = 0.0014) and control value...Continue Reading

References

Jan 1, 1951·Acta Orthopaedica Scandinavica·H J HANSEN
Feb 28, 2004·Journal of Neurotrauma·Natasha OlbyBruce Keene
Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
Sep 29, 2006·The Journal of Small Animal Practice·G FluehmannA Jaggy
Jun 15, 2007·The Veterinary Record·Y ChangJ Penderis
Mar 29, 2011·Journal of Neurotrauma·Jonathan M LevineLinda J Noble-Haeusslein
Jul 16, 2011·Journal of Neuropathology and Experimental Neurology·Ingo SpitzbarthAndreas Beineke
May 16, 2012·CNS & Neurological Disorders Drug Targets·Baukje J van der StarSandra Amor
May 23, 2012·Journal of the American Veterinary Medical Association·Niklas BergknutAnne-Sofie Lagerstedt
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marek J SąsiadekJoanna Bladowska
Jan 26, 2013·Journal of Magnetic Resonance Imaging : JMRI·John F GriffinJonathan M Levine
Mar 15, 2013·Frontiers in Neuroscience·José M SoaresNuno Sousa
Aug 7, 2013·World Neurosurgery·Alexander LernerMeng Law
Sep 10, 2013·Journal of Veterinary Internal Medicine·N D JefferyV M Stein
Sep 26, 2013·Neurosurgery·Aditya VedantamShekar N Kurpad
Oct 15, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Jocelyn J CooperJonathan M Levine
Feb 6, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Philipp HendrixR Shane Tubbs
Jun 18, 2014·ILAR Journal·Edward E Patterson
Jun 22, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Seyed Behzad JazayeriVafa Rahimi-Movaghar
Jul 26, 2014·NeuroImage. Clinical·Cyrus EierudStephen M LaConte
Jan 13, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·Y P Charles, J-P Steib
Jul 3, 2015·Biotechnology and Bioengineering·Andrea RaspaFabrizio Gelain
Oct 6, 2015·World Journal of Radiology·Shivanand GamanagattiVijay Sharma
Jan 30, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sjoerd B VosMartijn Froeling
Feb 2, 2016·Journal of the American Veterinary Medical Association·Nick D JefferyJonathan M Levine

❮ Previous
Next ❯

Citations

Dec 17, 2020·Frontiers in Veterinary Science·Natasha J OlbyUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT SCI)
Nov 17, 2020·Frontiers in Veterinary Science·Ronaldo C da CostaUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
Extended MR workspace ®
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.