PMID: 6987496Jan 1, 1980Paper

The role of dimer excision in liquid-holding recovery of UV-irradiated haploid yeast

Mutation Research
L R Ferguson, B S Cox

Abstract

We have directly tested the theory that liquid-holding recovery is due to an increase in the efficiency of excision-repair during holding in non-growth conditions, by assaying the dimers present in UV-irradiated cells held in saline, in growth medium or first in saline then in growth medium. We observed no differences in the amount of excision in any conditions. By assaying the kinetics of excision and comparing that with the timing of DNA synthesis, we have tested the theory that holding in growth medium allows more repair by extending the time available for it. We found that the observations were more consistent with the onset of DNA synthesis being dependent on the amount of repair rather than the converse. We have analysed the role of repair in liquid-holding recovery in a series of split-dose experiments. As Parry and Parry found, yeast cells which have been irradiated and held in non-growth conditions were much more resistant to further UV-irradiation. The increase in resistance was proportional both to the degree of fractionation of the dose and to the size of the first dose. No effect was observed if this was below 30 J . m-2. We found that the cells were able to excise more of the dimers induced if the UV dose was frac...Continue Reading

References

Feb 1, 1976·Genetics·C W Lawrence, R Christensen
Jan 1, 1975·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P E Bryant
Nov 1, 1975·Mutation Research·R WheatcroftR H Haynes
Dec 1, 1972·Mutation Research·J C Game, B S Cox
Feb 23, 1973·Biochimica Et Biophysica Acta·J Hatzfeld
Oct 1, 1973·Mutation Research·J C Game, B S Cox
Aug 1, 1974·Mutation Research·B Cox, J Game
Oct 1, 1974·Journal of Bacteriology·S H Moss, D J Davies
Jan 1, 1974·Molecular & General Genetics : MGG·L R Ferguson, B S Cox
Jan 1, 1968·Photochemistry and Photobiology·W Harm
Jan 1, 1969·Cold Spring Harbor Symposia on Quantitative Biology·D VazquezR E Monro

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Citations

Jan 1, 1982·Molecular & General Genetics : MGG·M G Lee, G T Yarranton
Jan 1, 1991·Radiation and Environmental Biophysics·S Hillebrandt, I Müller
Aug 1, 2000·Mutation Research·G B Sancar
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N Magaña-SchwenckeE Moustacchi
Jun 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E NunesA C Schenberg Frascino

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