The Role of Direct-acting Antivirals in the Treatment of Children with Chronic Hepatitis C

Journal of Clinical and Translational Hepatology
Christine Hong Ting YangAijaz Ahmed

Abstract

In the United States, chronic infection with the hepatitis C virus (HCV) affects an estimated 0.1-2% of the pediatric population, who are consequently at risk for major complications, including cirrhosis, hepatocellular carcinoma, and death. The current standard of treatment for chronic hepatitis C (CHC) in children is pegylated-interferon-alpha (PEG-IFN) in combination with ribavirin. PEG-IFN/ribavirin therapy is approved for children ages 3 and older; however, it is often held from use until adulthood because of its extensive list of potential side effects and high likelihood of causing adverse symptoms. While CHC is usually indolent in children and adolescents, immediately treating and curbing the spread of HCV before adulthood is important, as there can be transmission to other individuals via sexual activity and infected females can later vertically transmit the infection during pregnancy, the latter representing the most common means of transmission for children in the United States. The recent development of direct-acting antivirals has shown promising results in clinical trials for use in children and has dramatically increased the rates of sustained virological response in adults while improving side effect profiles as...Continue Reading

Citations

Jan 10, 2018·World Journal of Hepatology·Reza Taherkhani, Fatemeh Farshadpour
May 10, 2020·Journal of Viral Hepatitis·Nathan G KimSammy Saab

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Clinical Trials Mentioned

NCT01701063
NCT01590225
NCT02486406
NCT02175758
NCT02249182

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