PMID: 11343835May 10, 2001Paper

The role of dopamine in methylene blue-mediated inhibition of estradiol benzoate-induced anterior pituitary hyperplasia in rats

Neuroscience Letters
J NedvídkováV Schreiber

Abstract

Recently, we demonstrated that methylene blue partially inhibited estradiol-benzoate-induced anterior pituitary hyperplasia in rats. Since central dopaminergic systems participate in the regulation of estrogen-induced anterior pituitary growth and tumor transformation, this study examined whether a 3-week treatment with methylene blue could affect anterior pituitary levels of dopamine (DA), dihydroxyphenylalanine (DOPA), and dihydroxyphenylacetic acid and dopamine (D-2) receptors in male rats. Compared to controls, methylene blue significantly decreased anterior pituitary weight, increased basal anterior pituitary DA levels, and inhibited estradiol benzoate-induced decreases in anterior pituitary DA concentrations. Furthermore, we found that methylene blue alone decreased anterior pituitary D-2 receptor number. Methylene blue given in combination with estradiol benzoate partially inhibited estradiol benzoate-induced anterior pituitary growth and estradiol benzoate-induced increases in D-2 receptor number. Estradiol benzoate-treated rats had significantly lower anterior pituitary DOPA accumulation after intraperitoneal administration of 3,4-hydroxybenzyl-hydrazine dihydrochloride (NSD-1015), an irreversible inhibitor of L-aromat...Continue Reading

References

Dec 30, 1992·Biochemical and Biophysical Research Communications·N SchusslerN F Biguet
Feb 25, 2000·Biological Signals and Receptors·R K XuS F Pang

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Citations

Sep 18, 2009·Medicinal Research Reviews·Murat OzGeorge A Petroianu
Nov 18, 2020·Advanced Drug Delivery Reviews·Christian Isalomboto NkangaFarshad Ramazani

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