The role of dopaminergic immune cell signalling in poststroke inflammation

Therapeutic Advances in Neurological Disorders
Daniela TalhadaKarsten Ruscher

Abstract

Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke. Independent studies have revealed specific but different patterns of dopamine receptor subtypes on different populations of immune cells. Those patterns are dependent on the activation status of cells. Generally, exposure to dopamine or dopamine receptor agonists decreases detrimental actions of immune cells. In contrast, a reduction of dopaminergic inputs perpetuates a pro-inflammatory state associated with increased release of pro-inflammatory molecules. In addition, subsets of immune cells have been identified to synthesize and release dopamine, suggesting autore...Continue Reading

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Citations

Apr 24, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mikhail MelnikovMikhail Pashenkov
May 8, 2019·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Apr 16, 2019·Frontiers in Immunology·Fiona LimanaqiFrancesco Fornai
May 8, 2020·International Journal of Molecular Sciences·Min-Jeong HeoJin Hyuk Jung
Jul 1, 2020·Neural Regeneration Research·Sarah Thomas BroomeAlessandro Castorina
Oct 18, 2019·International Immunopharmacology·Qing-Peng XiaLing He
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Yiyi LiangHong Tu

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Methods Mentioned

BETA
flow cytometry
electrophoresis

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