The role of dynamic contrast-enhanced MRI in evaluation of percutaneous transluminal angioplasty outcome in patients with critical limb ischemia

European Journal of Radiology
Nikolaos GalanakisDimitrios Tsetis

Abstract

Imaging modalities such as CTA and MRA provide significant information about the distribution of macrovascular lesions of the limbs in patients with peripheral arterial disease but not for the local microvascular perfusion of the feet. The purpose of this study is to evaluate foot perfusion in patients with critical limb ischemia (CLI) and estimate percutaneous transluminal angioplasty (PTA) results, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Ten patients (6 male, median age 68 years) with CLI were examined. All patients underwent DCE-MRI of the lower limb before and within first month after PTA. Perfusion parameters such as blood flow (BF), Ktrans, Kep were analyzed and applied for statistical comparisons. The studies were also examined by a second observer to determine inter-observer reproducibility. Revascularization was technically successful in all patients and mean ankle brachial index (ABI) increased from 0.37 ± 0.18 to 0.76 ± 0.23, p < 0.05. After PTA, mean BF increased from 6.232 ± 2.867-9.867 ± 2.965 mL/min/100 g, Ktrans increased from 0.060 ± 0.022 to 0.107 ± 0.041 min-1 and Kep increased from 0.103 ± 0.024 to 0.148 ± 0.024 min-1, p < 0.05. All measurements demonstrated very good inter-obse...Continue Reading

References

Jul 1, 1991·Journal of Computer Assisted Tomography·G BrixW J Lorenz
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Mar 1, 1987·British Journal of Plastic Surgery·G I Taylor, J H Palmer
Jan 1, 1987·Magnetic Resonance Imaging·E K FramN J Pelc
May 24, 2001·The New England Journal of Medicine·W R Hiatt
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard B ThompsonRobert J Lederman
Jan 31, 2006·European Journal of Radiology·Christopher KlassenNorbert M Wilke
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Oct 9, 2008·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Vlad-Adrian AlexandrescuJacques Horion
Oct 20, 2012·British Medical Bulletin·P AbdulhannanS Homer-Vanniasinkam
Nov 22, 2012·Circulation. Cardiovascular Imaging·Amy W PollakChristopher M Kramer
Mar 19, 2016·Journal of the American College of Cardiology·Jeffrey W OlinWilliam R Hiatt
Feb 22, 2017·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K ŠpillerováM Venermo
Mar 28, 2017·Journal of Vascular Surgery·Hidde JongsmaBram Fioole
Jul 29, 2017·Journal of Magnetic Resonance Imaging : JMRI·Parvinder SujlanaLaura M Fayad
Oct 22, 2017·European Journal of Radiology·Pedro Vilela, Howard A Rowley
Aug 20, 2018·Magnetic Resonance Imaging·Georgios S IoannidisThomas G Maris
Nov 18, 2018·Journal of Magnetic Resonance Imaging : JMRI·Masoud EdalatiJie Zheng
Mar 27, 2019·Journal of Vascular and Interventional Radiology : JVIR·Nikolaos GalanakisDimitrios Tsetis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.