The Role of Early Bioelectric Signals in the Regeneration of Planarian Anterior/Posterior Polarity

Biophysical Journal
Fallon DurantMichael Levin

Abstract

Axial patterning during planarian regeneration relies on a transcriptional circuit that confers distinct positional information on the two ends of an amputated fragment. The earliest known elements of this system begin demarcating differences between anterior and posterior wounds by 6 h postamputation. However, it is still unknown what upstream events break the axial symmetry, allowing a mutual repressor system to establish invariant, distinct biochemical states at the anterior and posterior ends. Here, we show that bioelectric signaling at 3 h is crucial for the formation of proper anterior-posterior polarity in planaria. Briefly manipulating the endogenous bioelectric state by depolarizing the injured tissue during the first 3 h of regeneration alters gene expression by 6 h postamputation and leads to a double-headed phenotype upon regeneration despite confirmed washout of ionophores from tissue. These data reveal a primary functional role for resting membrane potential taking place within the first 3 h after injury and kick-starting the downstream pattern of events that elaborate anatomy over the following 10 days. We propose a simple model of molecular-genetic mechanisms to explain how physiological events taking place imme...Continue Reading

Citations

Sep 11, 2019·Journal of Experimental Botany·Jinwoo ShinPil Joon Seo
Dec 4, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Francisco HuizarJeremiah Zartman
Jan 30, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Levin
Feb 6, 2020·International Journal of Molecular Sciences·Paul G BarghouthNéstor J Oviedo
Dec 11, 2019·Scientific Reports·Santosh Manicka, Michael Levin
Jun 17, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Chris Fields, Michael Levin
Mar 5, 2020·Communicative & Integrative Biology·Chris Fields, Michael Levin
Jan 26, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alison Hanson
Feb 9, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Giovanni PezzuloMichael Levin
Aug 16, 2019·Progress in Biophysics and Molecular Biology·William B MillerFrantišek Baluška
May 23, 2020·Mechanisms of Development·Katherine B WilliamsMichael Levin
Aug 28, 2021·Bio Systems·Chris Fields, Michael Levin
Mar 1, 2020·Bioelectricity·David HealyMichael Levin

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