The role of early lineage in GABAergic and glutamatergic cell fate determination in Xenopus laevis

The Journal of Comparative Neurology
Mei LiM S Saha

Abstract

Proper functioning of the adult nervous system is critically dependent on neurons adopting the correct neurotransmitter phenotype during early development. Whereas the importance of cell-cell communication in fate determination is well documented for a number of neurotransmitter phenotypes, the contributions made by early lineage to this process remain less clear. This is particularly true for gamma-aminobutyric acid (GABA)ergic and glutamatergic neurons, which are present as the most abundant inhibitory and excitatory neurons, respectively, in the central nervous system of all vertebrates. In the present study, we have investigated the role of early lineage in the determination of these two neurotransmitter phenotypes by constructing a fate map of GABAergic and glutamatergic neurons for the 32-cell stage Xenopus embryo with the goal of determining whether early lineage influences the acquisition of these two neurotransmitter phenotypes. To examine these phenotypes, we have cloned xGAT-1, a molecular marker for the GABAergic phenotype in Xenopus, and described its expression pattern over the course of development. Although we have identified isolated examples of a blastomere imparting a statistically significant bias, when take...Continue Reading

References

Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C W WuenschellA J Tobin
Nov 23, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N DaleJ Storm-Mathisen
Aug 1, 1987·Developmental Biology·S A Moody
Jul 15, 1987·The Journal of Comparative Neurology·A RobertsJ Storm-Mathisen
Nov 1, 1985·Developmental Biology·J E Lamborghini, A Iles
Sep 1, 1980·The Journal of Comparative Neurology·D M LamY C Kong
Oct 23, 1997·The Journal of Comparative Neurology·S Huang, S A Moody
Aug 31, 2000·Developmental Biology·M C Lane, M D Sheets
Dec 18, 2001·Brain Research. Developmental Brain Research·C Frahm, A Draguhn
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 28, 2002·Current Opinion in Neurobiology·Carol Schuurmans, François Guillemot
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic
Jul 3, 2002·Nature Reviews. Neuroscience·Christo Goridis, Hermann Rohrer
Nov 28, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gaku Kumano, William C Smith
Nov 28, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mary Constance Lane, Michael D Sheets
Feb 21, 2003·Current Opinion in Neurobiology·Amy W Helms, Jane E Johnson
Apr 30, 2003·Pflügers Archiv : European journal of physiology·Nian-Hang ChenMichael W Quick
Jun 14, 2003·Neuroendocrinology·Christof GeigersederArtur Mayerhofer
Mar 24, 2004·Seminars in Cell & Developmental Biology·Xian-Jie Yang
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Goichi MiyoshiRyoichiro Kageyama
May 11, 2004·Nature Neuroscience·Alexandre PattynJean-François Brunet
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Conor W SipeMargaret S Saha
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Jun 29, 2004·Trends in Neurosciences·Pierre Vanderhaeghen, Franck Polleux
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Bret J Pearson, Chris Q Doe
Dec 25, 2004·Developmental Biology·Marthe J Howard

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Citations

Oct 4, 2007·BMC Developmental Biology·Jean-Philippe DullinMuriel Perron
Dec 30, 2014·Gene Expression Patterns : GEP·Andrew D HalleranMargaret S Saha
Feb 12, 2008·Gene Expression Patterns : GEP·Matthew R WesterMargaret S Saha
Oct 2, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brittany B LewisMargaret S Saha
Aug 18, 2006·Cells, Tissues, Organs·Annetrudi Kress, Lynne Selwood
Mar 9, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gwendolyn E KaeserMargaret S Saha
Jan 12, 2013·The Journal of Experimental Biology·Hideki KatowHirokazu Abe

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