The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies

Pharmacological Reports : PR
Paulina ZukowskaE M Slominska

Abstract

Ecto-5'-nucleotidase (e5NT, CD73) is an enzyme that is highly expressed in endothelium and is involved in the extracellular nucleotide catabolism. CD73 converts AMP to adenosine that via specific subtypes of P1 receptor mediates cytoprotection involving diverse mechanisms such as vasodilatation, suppression of inflammation, inhibition of thrombosis and anti-adrenergic effect. Physiological intravascular concentration of adenosine is in nanomolar range, but could become micromolar in response to various forms of stress. Endothelium is a major site for both CD73 mediated production of adenosine and its cytoprotective effect. Nucleotides (predominantly ATP or ADP) that could be released from different cells via controlled specific of unspecific mechanisms constitute a major source of substrate for adenosine production via CD73. Direct effects of extracellular nucleotides (mediated by P2 receptors) are typically opposite to adenosine P1 mediated activities. Retention of nucleotides and decreased adenosine production due to loss of CD73 function may have negative implications and could be important cause of various pathologies. Protective role of CD73 was indicated in ectopic calcification, atherosclerosis, rejection after xenotrans...Continue Reading

References

Nov 15, 1990·Biochemical and Biophysical Research Communications·M R KlemensL F Thompson
Jan 1, 1993·Journal of Neurochemistry·S James, P J Richardson
Jun 19, 1997·The American Journal of Cardiology·J C Shryock, L Belardinelli
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L AirasS Jalkanen
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lovisa HessleJosé Luis Millan
Dec 14, 2002·Blood·Peter C Burger, Denisa D Wagner
Jul 26, 2003·Nature Genetics·Frank RutschPeter Nürnberg
Aug 30, 2003·The Journal of Biological Chemistry·Vera Bianchi, Jozef Spychala
Apr 1, 1958·The Journal of Pathology and Bacteriology·J C POOLE, H W FLOREY
Oct 29, 2003·Circulation·Subodh VermaTodd J Anderson
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jussi NiemeläSirpa Jalkanen
Sep 3, 2004·The Journal of Clinical Investigation·Wilhelm Kriz
Dec 8, 2004·The Journal of Experimental Medicine·Linda F ThompsonSean P Colgan
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Foy N OsborneRyszard T Smolenski
Feb 14, 2006·The American Journal of Clinical Nutrition·Peter Libby
Mar 1, 2006·Cardiovascular Diabetology·Ricardo J EsperRogelio A Machado
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Oct 27, 2006·Nucleosides, Nucleotides & Nucleic Acids·A H Y YuenR T Smolenski
Mar 14, 2007·Circulation·Tobias EckleHolger K Eltzschig
Jul 28, 2007·Molecular and Cellular Biochemistry·Zain KhalpeyRyszard T Smolenski
Oct 27, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sirpa Jalkanen, Marko Salmi
Apr 12, 2008·Purinergic Signalling·Norbert Sträter
Apr 12, 2008·Purinergic Signalling·Sean P ColganLinda F Thompson
May 26, 2009·European Journal of Pharmacology·Vijay Kumar, Ambika Sharma
Sep 11, 2009·Anesthesiology·Holger K Eltzschig
Feb 4, 2011·The New England Journal of Medicine·Cynthia St HilaireManfred Boehm
Oct 1, 2011·Cardiovascular Research·Anja BuchheiserJürgen Schrader
Nov 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge B Cannata-AndiaKeith Hruska
May 5, 2012·Purinergic Signalling·Herbert ZimmermannNorbert Sträter
Sep 15, 2012·Cardiovascular Research·Yang Chul BöringJürgen Schrader
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Masanori OhtaHiroto Miura
Jan 16, 2013·Annals of the Royal College of Surgeons of England·Z KhalpeyR T Smolenski
Mar 28, 2013·British Journal of Pharmacology·Allan K N AlencarGisele Zapata-Sudo
Apr 23, 2013·Trends in Molecular Medicine·Luca AntonioliGyörgy Haskó

❮ Previous
Next ❯

Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Aug 2, 2016·Biological & Pharmaceutical Bulletin·Shun WatanabeTsuneo Kobayashi
Dec 3, 2016·Nucleosides, Nucleotides & Nucleic Acids·I Pelikant-MałeckaE M Słomińska
Oct 28, 2017·International Journal of Molecular Sciences·Takayuki Okamoto, Koji Suzuki
Jul 16, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Roman CovarrubiasRichard J Gumina
Jan 10, 2019·Nucleosides, Nucleotides & Nucleic Acids·Marta TomczykRyszard T Smolenski
Aug 15, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eva K HejbølHenrik D Schrøder
Jun 12, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyoshi AzumaTadashi Kaname
Mar 3, 2019·International Journal of Molecular Sciences·Zheng QiaoXuemei Ji
Jun 22, 2019·Immunotherapy·Siqi ChenBin Zhang
Sep 17, 2020·Hormones : International Journal of Endocrinology and Metabolism·Areta HebanowskaAlicja Braczko
Sep 1, 2017·Genome Biology and Evolution·Rafael Mina PiergiorgeMarcos Catanho
Jul 1, 2020·Terapevticheskiĭ arkhiv·N V Galeeva, I K Valeeva
May 16, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Takayuki OkamotoMotomu Shimaoka
Jun 3, 2021·Membranes·Deborah M BoesDuncan G G McMillan
Jun 19, 2021·Journal of Cellular and Molecular Medicine·Patrycja JablonskaEwa M Slominska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.