The Role of Electroconvulsive Therapy (ECT) in Bipolar Disorder: Effectiveness in 522 Patients with Bipolar Depression, Mixed-state, Mania and Catatonic Features

Current Neuropharmacology
Giulio PerugiMauro Mauri

Abstract

We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features. Of the original sample only 22 patients were excluded for the occurrence of side effects or consent withdrawal. After the ECT course, 344 (68.8%) patients were considered responders (final CGIi score ≤2) and 156 (31.2%) nonresponders. Response rates were respectively 68.1% for BD depression, 72.9% for mixed state, 75% for mania and 80.8% for catatonic features. Length of current episode and global severity of the illness were the only statistically significant predictors of nonresponse. ECT resulted to be an effective and safe treatment for all the phases of severe and drug-resistant BD. Positive response was observed in approximately two-thirds of the cases and in 80% of the catatonic patients. The duration of the current episode was the major ...Continue Reading

Citations

Mar 17, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Isabel MethfesselDavid Zilles
Dec 14, 2019·European Archives of Psychiatry and Clinical Neuroscience·Aida de Arriba-ArnauMikel Urretavizcaya
Dec 11, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Matthias BesseDavid Zilles
Dec 6, 2019·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHans Jurgen Moeller
May 6, 2019·International Journal of Bipolar Disorders·Christopher C AbbottMauricio Tohen
Jun 4, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Giulio E BrancatiGiulio Perugi
Jan 25, 2020·The Journal of ECT·Charles H Kellner, Muniza Anum Majoka
Dec 6, 2019·European Archives of Psychiatry and Clinical Neuroscience·Takahiro SodaBernhard T Baune
Apr 22, 2018·Molecular Psychiatry·Ross J BaldessariniGustavo H Vázquez
Jan 7, 2020·International Journal of Bipolar Disorders·Ross J BaldessariniLeonardo Tondo
Nov 11, 2020·The American Journal of Psychiatry·Alby EliasHarold A Sackeim
Feb 6, 2020·The Psychiatric Clinics of North America·Gabriele Sani, Alan C Swann
Feb 2, 2021·CNS Spectrums·Michael A Cummings, Jennifer A O'Day
Jun 2, 2020·Journal of Affective Disorders·Pierpaolo MeddaGiulio Perugi
May 8, 2021·Acta Psychiatrica Scandinavica·Isabel MethfesselDavid Zilles-Wegner
May 26, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Phern Chern TorColleen Loo
May 19, 2021·Journal of Affective Disorders·P Parker SchwabAdriana P Hermida
Dec 24, 2020·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiGreg Murray
Oct 10, 2021·Translational Psychiatry·Miklos ArgyelanAnil K Malhotra

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Catatonic Schizophrenia

Catatonia is a psychomotor symptom in which patients present with stupor, although catatonic excitement may also present at the other end of the spectrum. Catatonia has been historically associated with schizophrenia although it is also associated with other neuropsychiatric disorders. Find the latest research on catatonic schizophrenia here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.