The Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlation

Plastic and Reconstructive Surgery. Global Open
Linus T D ArmstrongMichelle P B Guppy

Abstract

The facial embryologic fusion planes as regions of mesenchymal and ectodermal fusion of the primordial facial processes during embryological development have been suggested to influence the spread, invasiveness, pathogenesis, and recurrence of cutaneous carcinoma. This study sought to establish whether basal cell carcinoma (BCC) originating in embryologic fusion planes has a greater propensity for earlier depth of invasion, leading to an increased rate of lesion recurrence. Facial BCCs excised in a single surgeon practice over 2 years were allocated into 2 anatomic domains according to their correlation with embryologic fusion planes. Lesion depth of invasion, surface area, and margins of excision were analyzed in conjunction with recurrence data over the following 70-80 months. Of the 331 lesions examined, 70 were located in embryologic fusion planes. No difference was found in the mean surface area and depth of invasion for lesions located in the 2 domains (P > 0.05). Ten lesion recurrences were identified, none of which were located in embryologic fusion planes. Recurrent lesions were excised with a significantly greater percentage of close and incomplete excision margins (P < 0.05). BCC arising in embryologic fusion planes ...Continue Reading

References

Aug 1, 1997·Archives of Otolaryngology--head & Neck Surgery·J D OsguthorpeM Hochman

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Citations

Mar 21, 2020·Advances in Skin & Wound Care·Ömer Faruk ÜnverdiOsman Serdar Berk
Nov 22, 2019·The Journal of Dermatological Treatment·Roberto Bueno FilhoCacilda da Silva Souza
Jul 17, 2019·Journal of the American Academy of Dermatology·Ashley WysongIren Kossintseva
Dec 14, 2019·Annales de dermatologie et de vénéréologie·J-M AmiciM Beylot-Barry

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Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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