The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells

Small GTPases
N Porther, M A Barbieri

Abstract

Metastasis is characterized pathologically by uncontrolled cell invasion, proliferation, migration and angiogenesis. It is a multistep process that encompasses the modulation of membrane permeability and invasion, cell spreading, cell migration and proliferation of the extracellular matrix, increase in cell adhesion molecules and interaction, decrease in cell attachment and induced survival signals and propagation of nutrient supplies (blood vessels). In cancer, a solid tumor cannot expand and spread without a series of synchronized events. Changes in cell adhesion receptor molecules (e.g., integrins, cadherin-catenins) and protease expressions have been linked to tumor invasion and metastasis. It has also been determined that ligand-growth factor receptor interactions have been associated with cancer development and metastasis via the endocytic pathway. Specifically, growth factors, which include IGF-1 and IGF-2 therapy, have been associated with most if not all of the features of metastasis. In this review, we will revisit some of the key findings on perhaps one of the most important hallmarks of cancer metastasis: cell migration and cell invasion and the role of the endocytic pathway in mediating this phenomenon.

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Citations

Dec 23, 2017·Cellular & Molecular Biology Letters·Jian GeBaowei Ji
Apr 25, 2018·Molecular and Cellular Biology·Jose Mercado-MatosLeslie M Shaw
Oct 3, 2018·Small GTPases·Kuldeep VermaSunando Datta
May 6, 2019·Cancers·Rafael PeláezIgnacio M Larrayoz
Jun 21, 2019·Cellular and Molecular Life Sciences : CMLS·Mathias Heikenwalder, Anna Lorentzen
Feb 26, 2020·International Journal of Molecular Sciences·Amaia Navarro-CorcueraMaría J Iraburu
Aug 5, 2020·Infection and Immunity·Ming-Xian ChenTang-Biao Shen
Jan 10, 2021·Journal of Cell Science·Krzysztof KolmusMarta Miączyńska
Jan 8, 2021·Biology·Elsi FerroCarlo C Campa
Nov 26, 2018·Biochemical and Biophysical Research Communications·Ping LiHong-Hong Pei
Jun 19, 2021·Frontiers in Cell and Developmental Biology·Hongyuan JinHangyu Li

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Methods Mentioned

BETA
GTPases
GTPase

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