PMID: 9450509Feb 5, 1998Paper

The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat

Life Sciences
K NakamotoT Itoh

Abstract

We investigated the role of endogenous gastric acid in the development of gastric ulcer from erosion induced by ischemia-reperfusion of the celiac artery in the rat. A half-hour clamping of the celiac artery (ischemia) caused acute gastric erosions 1 hour after reperfusion and such acute injuries progressed to ulcers 48-72 hours after reperfusion without any necrotizing agents. Gastric acid secretion decreased immediately after ischemia and didn't recover until 12 hours after reperfusion. Intraperitoneal administrations of cimetidine (100 mg/kg, every 12 hours) or omeprazole (30 mg/kg, every 24 hours) were started at 1, 6, or 12 hours after reperfusion. When administrations were started 1 hour after reperfusion, both drugs significantly decreased the total damaged area and prevented the progression of gastric erosions to ulcers. However, administrations started 6 or 12 hours after reperfusion failed to inhibit the total damaged area and to prevent ulcer formation. These results suggest that endogenous gastric acid may play an important role in the progression of gastric erosions to ulcers although ischemia itself reduces acid secretion. Furthermore, treatment with anti-acid-secretory drugs in the early stage of mucosal damage m...Continue Reading

Citations

Oct 20, 2012·World Journal of Gastroenterology : WJG·Zhang-Bo LiuJian-Fu Zhang
Mar 31, 2007·Life Sciences·Tohru KotaniKoji Takeuchi
May 11, 2005·World Journal of Gastroenterology : WJG·Li-Hong ZhangHe-Quan Li
Jul 15, 2011·Drug Testing and Analysis·John P Kelly
Apr 23, 2013·Journal of Internal Medicine·S Ares-SantosR Moratalla
May 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A StepensM Donaghy
Jan 1, 2010·The Journal of Pharmacology and Experimental Therapeutics·Yuka NakamoriKoji Takeuchi
Aug 4, 2011·The Journal of Pharmacology and Experimental Therapeutics·Gregory C HadlockAnnette E Fleckenstein
Nov 16, 2016·Brain and Behavior·Julius JuurmaaPille Taba
Oct 21, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tohru KotaniKoji Takeuchi

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