The role of endogenous glucocorticoids in rat experimental models of acute pancreatitis

Gastroenterology
R AbeT Toyota

Abstract

Cytokines activate the hypothalamic-pituitary-adrenal axis and suppress inflammation by stimulating glucocorticoid secretion. The state of adrenocortical function during acute pancreatitis and its role in this disease were determined. Cerulein-induced pancreatitis or closed duodenal loop pancreatitis was produced in rats that had undergone adrenalectomy or sham adrenalectomy, and the serum corticosterone and interleukin 8 levels and the intensity of the pancreatitis were examined. Serum corticosterone levels were significantly higher than basal levels in both models of experimental pancreatitis. In both models, adrenalectomy increased serum amylase and pancreatic edema and produced more severe inflammation. Adrenalectomy significantly increased mortality in animals with closed duodenal loop pancreatitis. Exogenous hydrocortisone administered to adrenalectomized animals suppressed the elevation of serum interleukin 8 levels and decreased both the severity of pancreatitis and mortality. These results suggest that the adrenocortical function is stimulated during acute pancreatitis and that the secretion of endogenous glucocorticoids may play an important role in mitigating the progress of this disease, probably by inhibiting cytok...Continue Reading

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Citations

Feb 18, 2006·Critical Care Medicine·Christophe A MullerWaldemar Uhl
Jul 28, 2009·Critical Care : the Official Journal of the Critical Care Forum·Yun-Shing PengMing-Hung Tsai
Jun 19, 2007·Intensive Care Medicine·Jan J De WaeleFrancis Colardyn
Sep 7, 2007·Digestive Diseases and Sciences·Jiaan-Der WangChieh-Chung Lin
Oct 28, 2009·Clinical Lymphoma & Myeloma·Franz-Xaver HuberChristian Kasperk
Feb 24, 2006·Molecular and Cellular Endocrinology·Danielle M H CavalcantiSandra H P Farsky
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Dec 11, 2014·World Journal of Gastroenterology : WJG·Swetha KambhampatiAida Habtezion
Nov 16, 2006·World Journal of Gastroenterology : WJG·Emad KandilMichael-E Zenilman
Aug 23, 2017·Molecular and Cellular Biochemistry·Yan ZhaoYuan-Guo Zhou
Apr 27, 2021·Annals of Medicine and Surgery·M BoualiA Fadil

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