The role of endogenous growth hormone-releasing hormone in acromegaly

The Journal of Clinical Endocrinology and Metabolism
Eleni V DimarakiAriel L Barkan

Abstract

Some indirect evidence suggests hypothalamic control of GH secretion in acromegaly. The objective of the study is to examine whether GH secretion in acromegaly is dependent on endogenous GHRH. We studied eight patients with untreated acromegaly due to a GH-producing pituitary tumor. All patients received an iv infusion of normal saline for 24 h and GHRH-antagonist (GHRH-ant) at 50 microg/kg x h for 7 d. GH was measured every 10 min for 24 h during the normal saline infusion and on the last day of the GHRH-ant infusion. A group of nine different patients with untreated acromegaly served as the control group and underwent blood sampling for GH every 10 min for two 24-h periods to assess the day-to-day variability of GH secretion. The study was set in a university referral center. Twenty-four-hour mean GH was the main outcome measured. In six of eight subjects treated with GHRH-ant, 24-h mean GH decreased by 5.8-30.0% during iv GHRH-ant and, in three subjects, the change in the 24-h mean GH was greater than the upper limit of the 95% confidence interval of the spontaneous day-to-day variability of the mean GH in patients with acromegaly. Based on the binomial distribution, the probability of this magnitude of change to occur in th...Continue Reading

References

Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M Saeed uz ZafarL A Frohman
Jan 1, 1992·Hormone Research·A Spada, L Vallar
Jul 1, 1990·The Journal of Clinical Investigation·J M AlexanderA Klibanski
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·V HermanS Melmed
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A L BarkanI Z Beitins
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N BillestrupW Vale
Aug 1, 1986·Clinics in Endocrinology and Metabolism·B W ScheithauerE R Laws
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A SpadaG Faglia
Feb 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M C GelatoJ Rivier
Feb 1, 1983·The Journal of Clinical Endocrinology and Metabolism·C B WebbL A Frohman
May 1, 1995·The Journal of Clinical Investigation·A ArnoldT B Drüeke
Dec 1, 1995·The Journal of Clinical Endocrinology and Metabolism·M SemerB Liberman
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ParadisP Bedossa
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·C A JaffeA L Barkan
Oct 1, 1995·Endocrine Pathology·Bernd W. ScheithauerDudley H. Davis
Dec 9, 2003·The Journal of Clinical Investigation·Shlomo Melmed

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Citations

Dec 18, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Andrew V SchallyJörg B Engel
Mar 2, 2012·Neuroendocrinology·Luca SzalontayMagdolna Kovacs
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Andy Levy
Feb 3, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoko KojimaYuzo Furuya
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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