PMID: 8612019Feb 1, 1996Paper

The role of endogenous serotonin in adjuvant-induced arthritis in the rat

British Journal of Rheumatology
M S HarbuzH S Chowdrey

Abstract

We have investigated the effects of serotonin depletion on the progress and severity of adjuvant-induced arthritis in the Piebald-Viral-Glaxo (PVG) strain of rat. Total body depletion of serotonin was achieved using p-chlorophenylalanine given i.p. Two paradigms were investigated. First we depleted serotonin at the time of injection of the adjuvant to determine whether serotonin was involved in the initial induction phase. Secondly, we depleted serotonin at the time of onset of the inflammation. Serotonin levels in the hypothalamic paraventricular nucleus (PVN) were reduced by > 95%. Depletion at the time of induction had no effect on the severity of the disease (determined by the increase (determined by the increase in hind paw volume) 14 days after injection of the adjuvant. In contrast, depletion at the time of onset of the disease resulted in a significant reduction in severity at day 14, suggesting a pro-inflammatory role for serotonin in this model. The decrease in corticotrophin-releasing factor (CRF) mRNA in the PVN associated with the development of adjuvant arthritis in PVG rat was reversed in the serotonin-depleted animals. Central serotonin could be one of the factors responsible for the reduced expression of CRF mR...Continue Reading

Citations

Aug 17, 2005·International Immunopharmacology·Nasrin MalekiAlireza Garjani
Jun 18, 1998·Annals of the New York Academy of Sciences·N ShanksS L Lightman
Jan 6, 2010·Molecular Interventions·Martin Pelletier, Richard M Siegel
May 16, 2006·Annals of the Rheumatic Diseases·A KlingT Mjörndal
Aug 15, 2009·Arthritis Research & Therapy·Eugene Y Kim, Kamal D Moudgil
Sep 6, 2012·Current Rheumatology Reports·Matthias F Seidel, Nancy E Lane
Mar 7, 2012·Drug Discovery Today·Gohar FakhfouriAhmad R Dehpour
Aug 27, 2009·Gastroenterology·Jean-Eric GhiaWaliul I Khan
May 12, 2009·Journal of Ethnopharmacology·Eduardo Koji TamuraSandra H P Farsky
Jul 22, 1999·Archives of Oral Biology·K TominagaS Kopp
Oct 4, 2014·Behavioural Brain Research·Nina StrennAgneta Ekman
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Signe F BomholtRuth E Blackburn-Munro
Jan 31, 2006·Nature Immunology·Bryce A BinstadtChristophe Benoist
Aug 14, 2018·International Review of Psychiatry·Thomas W Flanagan, Charles D Nichols
Aug 14, 1997·Annals of the New York Academy of Sciences·M S HarbuzD S Jessop
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·M S Harbuz, D S Jessop
Jul 31, 2001·Journal of Clinical Psychopharmacology·S D HoodD J Nutt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.