PMID: 15218402Jun 26, 2004Paper

The role of endothelial lipase in high-density lipoprotein metabolism

Current Opinion in Cardiology
Karen O Badellino, D J Rader

Abstract

Elevating high-density lipoprotein levels is increasingly being identified as an essential strategy for the prevention of atherosclerosis. Plasma levels of high-density lipoprotein cholesterol and its major protein, apoAI, are largely influenced by the rate of turnover. Lipases play an important role in modulating the metabolism of high-density lipoprotein. In particular, endothelial lipase has been shown to be an important determinant of high-density lipoprotein metabolism and levels in murine models. This article reviews new developments in our understanding of the biology of endothelial lipase and its relation to high-density lipoprotein metabolism. Inhibition of the endothelial lipase gene, either by antibody injection or by targeted gene deletion, results in an approximately 50% increase in high-density lipoprotein cholesterol levels in mice. As many as 31 single-nucleotide polymorphisms have been identified in the endothelial lipase gene. The 584 C/T mutation, which results in a threonine-to-isoleucine amino acid change, has been associated with higher high-density lipoprotein cholesterol levels in three separate studies. Increasing evidence suggests that endothelial lipase plays a significant role in high-density lipopro...Continue Reading

References

Apr 7, 1999·Nature Genetics·M JayeD J Rader
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Jun 29, 2000·Biochemical and Biophysical Research Communications·K HirataT Quertermous
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Mar 17, 2004·Current Opinion in Lipidology·Michael Jaye, John Krawiec

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Citations

Jul 12, 2011·Current Atherosclerosis Reports·Kuang-Yuh ChyuPrediman K Shah
Jul 2, 2009·The Journal of Biological Chemistry·Nathalie GriffonDaniel J Rader
Jul 19, 2008·Circulation Research·Robert J Brown, Daniel J Rader
Jan 25, 2011·Cardiology Clinics·Kuang-Yuh Chyu, Prediman K Shah
Dec 3, 2010·Journal of Clinical Lipidology·Peter P Toth, Michael H Davidson
May 15, 2007·Gastroenterology·Vaneeta Bamba, Daniel J Rader
Nov 9, 2006·Journal of Lipid Research·Lyndon J MitnaulErik G Lund
May 15, 2007·Current Opinion in Lipidology·Benoît Lamarche, Marie-Eve Paradis
Sep 22, 2007·Current Opinion in Lipidology·Cai Li
Mar 22, 2014·Expert Review of Cardiovascular Therapy·Eleni A KaraviaKyriakos E Kypreos
Jun 21, 2008·Journal of Biomolecular Screening·Paul M KellerBenjamin Schwartz
Oct 31, 2013·Journal of Medicinal Chemistry·Luke J LemanM Reza Ghadiri

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