PMID: 8587695Jul 1, 1995Paper

The role of endothelin in experimental cerebral vasospasm

Neurosurgery
S RouxJ P Clozel

Abstract

Endothelin (ET) may play a role in vasospasm after subarachnoid hemorrhage (SAH). The aim of our study was to test whether the systemic administration of bosentan, a nonpeptidic ET(A) and ETB receptor antagonist, could reverse vasospasm without inducing hypotension. In rabbits (single-hemorrhage model) and in dogs (double-hemorrhage model), SAH was induced; after vasospasm was established, the animals received intravenously either saline or a 30 mg/kg bolus of bosentan. The cross-sectional area of the basilar artery was analyzed by quantitative angiography. In rabbits (n = 13), bosentan reversed basilar vasospasm to the same extent as did an intravertebral injection of sodium nitroprusside. In dogs (n = 10), bosentan reversed only 52 +/- 10% of the vasospasm reversible by papaverine. Bosentan did not alter the heart rate or the arterial blood pressure in either the rabbits or the dogs. In the cerebrospinal fluid, SAH increased endothelin-1 (ET1) and big ET1 by 6 and 3.8 times, respectively; in the basilar artery, SAH increased ET1 concentration, big ET1 concentration, and ET-converting enzyme activity by 1.3, 2, and 2.7 times, respectively. In addition, a local involvement of ET was also suggested by the relaxing effect of bose...Continue Reading

References

Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H EhrenreichF D Goebel
Dec 1, 1992·Journal of Neurosurgery·N F KassellW S Cail
Aug 1, 1992·Journal of Neurosurgery·E H Ohlstein, B L Storer
Mar 25, 1991·Biochemical and Biophysical Research Communications·D L WilliamsB V Clineschmidt
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·R L Macdonald, B K Weir
Apr 17, 1991·European Journal of Pharmacology·T M CocksJ A Angus
May 1, 1991·Neurosurgery·H KobayashiH Ide
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·S YoshimotoS Murota
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MatsuiT Asano
Jun 1, 1991·Journal of Neurosurgery·T ShigenoK Yamada
Nov 13, 1990·European Journal of Pharmacology·T AsanoH Hidaka
Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·T MimaT Masaki
Jan 1, 1983·Methods in Enzymology·P J Munson
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·F Cosentino, Z S Katusić
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SakoS Sakaki
Feb 1, 1993·The American Journal of Physiology·V K BatraV Gopalakrishnan

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Citations

Jan 1, 1997·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G I FegerM Wahl
Jan 20, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·SeongHun YoonRobert M Rapoport
Jan 20, 2004·European Journal of Pharmacology·Angelica WackenforsMalin Malmsjö
Sep 30, 2000·European Journal of Pharmacology·L R WhiteJ Aasly
Aug 17, 1999·European Journal of Pharmacology·E UddmanL Edvinsson
Jan 1, 1996·Pharmacology & Therapeutics·G A Gray, D J Webb
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander Y. ZubkovJohn H. Zhang
Dec 4, 2002·Nature Reviews. Drug Discovery·Giuseppe RemuzziAriela Benigni
Oct 20, 1998·Acta Physiologica Scandinavica·L R WhiteL Edvinsson
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A HinoR L Macdonald
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O TouzaniJ McCulloch
Sep 8, 2000·Journal of Cardiovascular Pharmacology·M Clozel
Sep 8, 2000·Journal of Cardiovascular Pharmacology·B M Löffler
Sep 19, 2012·Journal of Cardiovascular Pharmacology·Robert M Rapoport, Mario Zuccarello
Nov 1, 1996·British Journal of Pharmacology·M AdnerL Edvinsson
Nov 26, 2002·Neurosurgery·Michael ChowNeal F Kassell
Feb 13, 2001·Biochemical and Biophysical Research Communications·G LinB K Weir
May 1, 1997·Expert Opinion on Investigational Drugs·S J Haleen, X M Cheng
Jul 5, 2005·Expert Opinion on Investigational Drugs·V BreuM Clozel
Aug 24, 2010·British Journal of Neurosurgery·Serge MarbacherNeil D Kitchen
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
May 15, 2010·Cellular Signalling·Al-Karim Khimji, Don C Rockey
May 7, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kamil G LabanH Bart van der Worp
Oct 30, 2007·European Journal of Pharmacology·David NilssonMalin Malmsjö
May 3, 2006·European Journal of Pharmacology·Guogang LuoCang-Bao Xu
Apr 26, 2001·Neurological Research·M Zwienenberg, J P Muizelaar
Mar 21, 2003·The Annals of Thoracic Surgery·Angelica WackenforsMalin Malmsjö

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