The role of endothelium in cardiovascular homeostasis and diseases

Journal of Cardiovascular Pharmacology
G M Rubanyi

Abstract

Key discoveries in the past decade have revealed that the vascular endothelium is an important regulatory organ that is involved in maintaining cardiovascular homeostasis in health and contributes significantly to the pathomechanism of several cardiovascular diseases. Occupying a strategically important location between circulating blood and tissues and having the ability to respond to changes in its physical, chemical, and humoral environment by the production of a host of biologically active substances, the normal endothelium modulates the tone of underlying vascular smooth muscle, maintains a nonadhesive luminal surface, and mediates hemostasis, cellular proliferation, and inflammatory and immune mechanisms in the vascular wall. Modulation of smooth-muscle tone is mediated by the synthesis release of endothelium-derived relaxing [PGI2, EDRF(NO), and EDHF] and contracting factors (arachidonic acid metabolites, endothelin-1, and angiotensin II). Anticoagulant, fibrinolytic, and antithrombotic properties contribute to the maintenance of the fluidity of blood. Injury or activation (by cytokines) of endothelial cells disrupts these normal regulatory mechanisms and results in morphologic and functional alterations (phenotypic chan...Continue Reading

Citations

Nov 11, 1999·Clinical Cardiology·J M Wilson, J J Ferguson
May 26, 2010·European Journal of Applied Physiology·Thaís de Oliveira FariaJuliana Hott de Fúcio Lizardo
Jun 20, 2006·Annals of Biomedical Engineering·Brett C IsenbergRobert T Tranquillo
Oct 13, 2006·The International Journal of Cardiovascular Imaging·Merih BaykanSükrü Celik
Apr 28, 2005·Free Radical Biology & Medicine·Scott W Ballinger
Jan 30, 2004·Vascular Pharmacology·Jorge González-Pérez, María J Crespo
Mar 29, 2005·Vascular Pharmacology·Folkert W AsselbergsWiek H van Gilst
Dec 22, 1998·The American Journal of Cardiology·H Drexler
Oct 4, 2000·The Annals of Thoracic Surgery·I KrassóiJ G Papp
May 22, 2002·European Journal of Pharmacology·Mercedes SanzTeresa Tejerina
Mar 24, 2000·Atherosclerosis·A G ZamanJ J Badimon
Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
Jun 1, 1997·Thrombosis Research·J O'GradyH Sinzinger
Feb 1, 1997·International Journal of Cardiology·J KowalskiJ Paśnik
Oct 17, 2002·Vascular Pharmacology·Gabor M RubanyiKatalin Kauser
Jan 12, 2001·Journal of the American College of Cardiology·N P AndrewsA A Quyyumi
Jul 27, 2002·Journal of the American College of Cardiology·Maria G ModenaRosario Rossi
Aug 1, 1997·Journal of the American College of Cardiology·D S Celermajer
Aug 10, 1999·Journal of the American College of Cardiology·A PrasadA A Quyyumi
Jan 15, 2000·Journal of the American College of Cardiology·P C Deedwania
Nov 7, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M MorgantiR Giardino
Jun 18, 2002·European Journal of Internal Medicine·Stamatis AdamopoulosDimitrios Th. Kremastinos

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