PMID: 9529624Apr 8, 1998Paper

The role of endothelium in human hypertension

Current Opinion in Nephrology and Hypertension
S TaddeiA Salvetti

Abstract

Endothelium-derived nitric oxide is not only a potent vasodilator but also inhibits platelet aggregation, smooth muscle cell proliferation, monocyte adhesion and adhesion molecule expression. In several pathological conditions, such as human hypertension, nitric oxide availability is reduced. This alteration has been documented in the peripheral and coronary micro- and macrocirculation and in the renal circulation. The main mechanism leading to endothelial dysfunction is production of cyclooxygenase-dependent factors, including prostanoids and oxygen free radicals, which cause nitric oxide breakdown. Dysfunctional endothelium can be one of the main mechanisms causing vascular damage, in particular, atherosclerosis; hence, an important aim for antihypertensive treatment could reside not only in normalizing blood pressure values but also in reversing endothelial dysfunction. Available evidence indicates that different classes of antihypertensive compounds have different effects on endothelial dysfunction.

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Citations

Sep 12, 2000·Current Hypertension Reports·S TaddeiA Salvetti
Nov 22, 2001·Current Hypertension Reports·L V d'Uscio, T F Lüscher
Apr 23, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eberhard SchulzThomas Münzel
Oct 13, 2000·European Journal of Clinical Investigation·C G SchalkwijkC D Stehouwer
Jan 29, 2002·Journal of Cardiovascular Pharmacology·S TaddeiA Salvetti
Nov 13, 2007·Clinical and Experimental Hypertension : CHE·Jie LiYuan-Jian Li
Jul 12, 2008·European Journal of Pharmacology·Magdalena DudekLidia Włodek
Dec 13, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gursharan DograGerald Watts
Mar 30, 2007·Fundamental & Clinical Pharmacology·Ramón RodrigoRoberto Charles
Feb 12, 2011·Basic & Clinical Pharmacology & Toxicology·Zhuoming LiPaul M Vanhoutte
Jan 25, 2003·Journal of Hypertension·Sàndor TúriIlona Németh
Jul 28, 2009·British Journal of Pharmacology·Daniele VersariStefano Taddei
May 5, 2020·Antioxidants & Redox Signaling·Yin WuMing-Hui Zou

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