PMID: 9184813May 1, 1997Paper

The role of endothelium in the calcium-induced reduction of the contractile response of the rabbit aorta

General Pharmacology
A OrtegaAmaya Aleixandre

Abstract

1. Increase of Ca2+ concentration in the bath solution diminishes the contractile response of isolated rabbit aorta rings to alpha 1-adrenoceptor agonists and KCl. 2. In intact preparations the contractions of methoxamine and phenylephrine were maximal when a 0.3- to 0.6-mM Ca2+ bath solution was used, and those of KCl were maximal with a 2.5-mM Ca2+ concentration. 3. The contractions of methoxamine and phenylephrine also were decreased by increasing the Ca2+ concentration above 1.25 mM in disrupted endothelium preparations and in those incubated in indomethacin (10(-5) M), N omega-nitro-L-arginine methyl ester (10(-4) M), or methylene blue (10(-6) M). 4. High organ bath Ca2+ concentrations also caused a decrease in KCl contractions using endothelium-denuded and the treated preparations, the responses being similar with 1.25 mM and 2.5-mM Ca2+ in the methylene blue-treated preparations, whereas they were greater with 1.25 mM Ca2+ in the others.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W R KukovetzG Pöch
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Jan 1, 1986·Journal of Cardiovascular Pharmacology·C van BreemenR Loutzenhiser
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·J R DochertyK Starke
Feb 15, 1963·Science·D F Bohr

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Citations

Dec 13, 2001·European Journal of Pharmacology·A O Mateo, M A de Artiñano

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