The role of environmental exposures and the epigenome in health and disease

Environmental and Molecular Mutagenesis
Bambarendage P U PereraDana C Dolinoy

Abstract

The genetic material of every organism exists within the context of regulatory networks that govern gene expression, collectively called the epigenome. Epigenetics has taken center stage in the study of diseases such as cancer and diabetes, but its integration into the field of environmental health is still emerging. As the Environmental Mutagenesis and Genomics Society (EMGS) celebrates its 50th Anniversary this year, we have come together to review and summarize the seminal advances in the field of environmental epigenomics. Specifically, we focus on the role epigenetics may play in multigenerational and transgenerational transmission of environmentally induced health effects. We also summarize state of the art techniques for evaluating the epigenome, environmental epigenetic analysis, and the emerging field of epigenome editing. Finally, we evaluate transposon epigenetics as they relate to environmental exposures and explore the role of noncoding RNA as biomarkers of environmental exposures. Although the field has advanced over the past several decades, including being recognized by EMGS with its own Special Interest Group, recently renamed Epigenomics, we are excited about the opportunities for environmental epigenetic scie...Continue Reading

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Citations

Mar 8, 2020·Environmental and Molecular Mutagenesis·Brunella Del Re, Gianfranco Giorgi
Jan 31, 2020·Frontiers in Endocrinology·Xuejiao ChenGuowei Li
Jul 27, 2020·Environmental Epigenetics·Jill Escher, La Donna Ford
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Feb 6, 2020·Current Environmental Health Reports·Joseph Kochmanski, Alison I Bernstein
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Jul 22, 2021·Cell and Tissue Research·Gianfranco Giorgi, Brunella Del Re
Aug 28, 2021·International Journal of Molecular Sciences·Laura Leo, Nunzia Colonna Romano

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