The genetic material of every organism exists within the context of regulatory networks that govern gene expression, collectively called the epigenome. Epigenetics has taken center stage in the study of diseases such as cancer and diabetes, but its integration into the field of environmental health is still emerging. As the Environmental Mutagenesis and Genomics Society (EMGS) celebrates its 50th Anniversary this year, we have come together to review and summarize the seminal advances in the field of environmental epigenomics. Specifically, we focus on the role epigenetics may play in multigenerational and transgenerational transmission of environmentally induced health effects. We also summarize state of the art techniques for evaluating the epigenome, environmental epigenetic analysis, and the emerging field of epigenome editing. Finally, we evaluate transposon epigenetics as they relate to environmental exposures and explore the role of noncoding RNA as biomarkers of environmental exposures. Although the field has advanced over the past several decades, including being recognized by EMGS with its own Special Interest Group, recently renamed Epigenomics, we are excited about the opportunities for environmental epigenetic scie...Continue Reading
Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements
Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit
Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study
Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles
Timing is everything: the when and how of environmentally induced changes in the epigenome of animals
Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms
Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures
Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure
Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis
Different measures of "genome-wide" DNA methylation exhibit unique properties in placental and somatic tissues
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19
From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation.
Long Term Risks to Neonatal Health from Exposure to War-9 Years Long Survey of Reproductive Health and Contamination by Weapon-Delivered Heavy Metals in Gaza, Palestine
Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs
Bioactive food compounds, epigenetics and chronic disease prevention: Focus on early-life interventions with polyphenols
Embryonic Exposure to Low Concentrations of Bisphenol A and S Altered Genes Related to Pancreatic β-Cell Development and DNA Methyltransferase in Zebrafish.
Association between H3K36me3 modification and methylation of LINE-1 and MGMT in peripheral blood lymphocytes of PAH-exposed workers
Environmentally Induced Epigenetic Transgenerational Inheritance and the Weismann Barrier: The Dawn of Neo-Lamarckian Theory
Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis
Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields.
Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana.
Emerging Single-Cell Technological Approaches to Investigate Chromatin Dynamics and Centromere Regulation in Human Health and Disease.
Biomarkers for Diabetes
This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.