The role of enzymatic antioxidants detected in the follicular fluid and semen of infertile couples undergoing assisted reproduction

Human Fertility : Journal of the British Fertility Society
Eleonora B PasqualottoF F Pasqualotto

Abstract

The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development. The goal of our study was to evaluate the oxidative stress markers in the semen, blood serum, and follicular fluid of couples undergoing Intracytoplasmic Sperm Injection (ICSI). Two hundred and eight infertile couples underwent ICSI and the levels of superoxide dismutase (SOD) and catalase and lipid peroxidation (LPO) were evaluated. Semen Catalase was highly correlated with fertilization and cleavage rates, but not with pregnancy rates. Fertilization and cleavage rates were correlated with the levels of SOD and Catalase in the follicular fluid. After adjusting for age, a negative correlation was detected between LPO levels in follicular fluid and pregnancy rates. Follicular fluid LPO levels may be a marker as a metabolic activity within the follicle need for establishing a pregnancy.

References

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Citations

Feb 19, 2013·Reproductive Biomedicine Online·Agne VelthutAndres Salumets
Dec 10, 2014·Journal of Assisted Reproduction and Genetics·Aslıhan PekelHasan Kafalı
Feb 26, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nafiye YilmazAyten Turkkani
Nov 1, 2018·Reproductive Medicine and Biology·Takuji NishiharaYoshiharu Morimoto
Sep 10, 2020·Biology·Alexandra Almansa-OrdonezFilippo Zambelli
Nov 30, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Raziye ŞentürkDuygu Kumbul Doğuç

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