The role of enzymatic processing in the biological actions of substance P.

Peptides
M E HallJ M Stewart

Abstract

There is considerable evidence that substance P (SP) is a neurotransmitter in the CNS. Current findings suggest that the effects of synaptically released SP are terminated by enzymatic breakdown, primarily by endopeptidase 3.4.24.11 (endo 24.11). The products of cleavage by endo 24.11 include the amino-terminal fragment SP(1-7). Evidence suggests that SP is involved in mediating baroreceptor reflex activity in the nucleus of the solitary tract (NTS). Microinjection of SP into the NTS lowered blood pressure and heart rate. Microinjection of SP(1-7) into the NTS reproduced the effects of SP on both heart rate and blood pressure. Intra-NTS injection of phosphoramidon, an inhibitor of endo 24.11 activity, completely blocked the effects of a subsequent injection of SP. This blocking effect of phosphoramidon was unaltered by pretreatment with the opiate inhibitor naloxone. In contrast, phosphoramidon failed to block the depressor and bradycardic effects of SP(1-7). The implications of these findings regarding the role of endo 24.11 in the metabolism of SP are discussed.

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Citations

Feb 9, 1995·Journal of the Autonomic Nervous System·F MartiniJ J Puizillout
Apr 24, 1991·Brain Research. Developmental Brain Research·B J MeyersonP Le Grevés
Jan 23, 1995·Behavioural Brain Research·J P Huston, R U Hasenöhrl
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Jan 1, 1991·Annals of the New York Academy of Sciences·M E HallJ M Stewart
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Aug 2, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Antonella CavazzaAngela Valenti
Nov 23, 2006·Journal of Pharmaceutical and Biomedical Analysis·Arvind K ChappaSusan M Lunte
Jul 27, 2005·Peptides·Lu Liu, Elizabeth Burcher
May 4, 2010·Current Biology : CB·Sandrine M DupréAndrew S I Loudon
Jan 1, 1991·Annals of the New York Academy of Sciences·S H BuckP L van Giersbergen
Jan 22, 1993·Brain Research·D P Geraghty, E Burcher

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