The role of epigenetics in the reproductive toxicity of environmental endocrine disruptors.

Environmental and Molecular Mutagenesis
Yanbin ShiLin Ye

Abstract

Environmental endocrine disruptors (EEDs) seriously endanger human health by interfering with the normal function of reproductive systems. In males, EEDs can affect sperm formation and semen quality as well spermatogenesis, ultimately reducing fertility. In females, EEDs can affect uterine development and the expression levels of reproduction-related genes, ultimately reducing female fertility and the normal development of the fetus. There are a large number of putative mechanisms by which EEDs can induce reproductive toxicity, and many studies have shown the involvement of epigenetics. In this review, we summarize the role of DNA methylation, noncoding RNAs, genomic imprinting, chromatin remodeling and histone modification in the reproductive toxicity of EEDs.

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Citations

Feb 10, 2021·International Journal of Environmental Research and Public Health·Saira AmirAristidis Tsatsakis
Feb 15, 2021·Ecotoxicology and Environmental Safety·Yingchun ZhangZhixian Gao
Apr 10, 2021·Frontiers in Cell and Developmental Biology·Meng-Hao PanBaohua Ma
Sep 25, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·L GaspariS Hamamah

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